Evidence map›Paper›PMID 28299208›Full record

ArticleNeural plasticity2017

Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell's Palsy.

Wenwen Song, Minhui Dai, Lihua Xuan, Zhijian Cao, Sisi Zhou, Courtney Lang, Kun Lv, Maosheng Xu, Jian Kong

Open access · goldAbstract read
In one paragraph

Article in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Wenwen SongThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0002-8810-0756
Minhui DaiThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Lihua XuanThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Zhijian CaoThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Sisi ZhouThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Courtney LangDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Kun LvThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Maosheng XuThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0000-0002-2396-1600
Jian KongDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0002-2744-6067
Zhejiang Chinese Medical University · CNHarvard University · US

Funding

The Role of Context Effect in Acupuncture Treatment of Low Back/J.KongP01AT006663 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HIRSCHTICK, RANDY L, ROSEN, BRUCE R · 2011 to 2017
$10.0M
Neuromodulation of placebo and nocebo effectsR01AT008563 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2015 to 2019
$3.9M
The Neurobiology of Placebo and Nocebo Effects: A Brain Imaging StudyR01AT006364 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2011 to 2015
$3.6M
Neural dynamics of directly and indirectly conditioned placebo/nocebo effectR21AT008707 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$479k
NCCIH NIH HHS P01 AT006663NCCIH NIH HHS R01 AT006364NCCIH NIH HHS R01 AT008563NCCIH NIH HHS R21 AT008707
6 · The paper itself

Abstract

Neuroplasticity is a common phenomenon in the human brain following nerve injury. It is defined as the brain's ability to reorganize by creating new neural pathways in order to adapt to change. Here, we use task-related and resting-state fMRI to investigate neuroplasticity in the primary sensory (S1) and motor cortex (M1) in patients with acute Bell's palsy (BP). We found that the period directly following the onset of BP (less than 14 days) is associated with significant decreases in regional homogeneity (ReHo), fractional amplitude of low frequency fluctuations (fALFF), and intrinsic connectivity contrast (ICC) values in the contralateral S1/M1 and in ReHo and ICC values in the ipsilateral S1/M1, compared to healthy controls. The regions with decreased ReHo, fALFF, and ICC values were in both the face and hand region of S1/M1 as indicated by resting-state fMRI but not task-related fMRI. Our results suggest that the early stages of BP are associated with functional neuroplasticity in both the face and hand regions of S1/M1 and that resting-state functional fMRI may be a sensitive tool to detect these early stages of plasticity in patient populations.

Indexed as

Neuronal PlasticityAdultBell PalsyBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotor CortexNeural PathwaysSomatosensory CortexYoung Adult

Identifiers

PMID28299208
PMCPMC5337373
OpenAlexW2588336650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.