Evidence map›Paper›PMID 28298952›Full record

ReviewOxidative medicine and cellular longevity2017

Insights for Oxidative Stress and mTOR Signaling in Myocardial Ischemia/Reperfusion Injury under Diabetes.

Dajun Zhao, Jian Yang, Lifang Yang

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 163 citations in OpenAlex.

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  8. Innateness transcriptome gradients characterize mouse T lymphocyte populations.Journal of immunology (Baltimore, Md. : 1950) · 2025
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dajun ZhaoDepartment of Cardiac Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
Jian YangDepartment of Cardiac Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0003-2059-1912
Lifang YangDepartment of Anesthesiology, Xi'an Children's Hospital, Xi'an 710003, China.ORCID 0000-0002-4004-9883
Xijing Hospital · CNXi’an Children’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) displays a high morbidity. The diabetic heart is susceptible to myocardial ischemia/reperfusion (MI/R) injury. Impaired activation of prosurvival pathways, endoplasmic reticulum (ER) stress, increased basal oxidative state, and decreased antioxidant defense and autophagy may render diabetic hearts more vulnerable to MI/R injury. Oxidative stress and mTOR signaling crucially regulate cardiometabolism, affecting MI/R injury under diabetes. Producing reactive oxygen species (ROS) and reactive nitrogen species (RNS), uncoupling nitric oxide synthase (NOS), and disturbing the mitochondrial quality control may be three major mechanisms of oxidative stress. mTOR signaling presents both cardioprotective and cardiotoxic effects on the diabetic heart, which interplays with oxidative stress directly or indirectly. Antihyperglycemic agent metformin and newly found free radicals scavengers, Sirt1 and CTRP9, may serve as promising pharmacological therapeutic targets. In this review, we will focus on the role of oxidative stress and mTOR signaling in the pathophysiology of MI/R injury in diabetes and discuss potential mechanisms and their interactions in an effort to provide some evidence for cardiometabolic targeted therapies for ischemic heart disease (IHD).

Indexed as

Oxidative StressAdiponectinAnimalsAntioxidantsDiabetes ComplicationsDiabetes MellitusEndoplasmic ReticulumGlycoproteinsHumansHypoglycemic AgentsMiceMitochondriaMyocardial IschemiaMyocardial Reperfusion InjuryNitric Oxide SynthaseQuality ControlAdiponectinAntioxidantsC1QTNF9B protein, humanGlycoproteinsHypoglycemic AgentsMTOR protein, humanNitric Oxide SynthaseReactive Nitrogen SpeciesReactive Oxygen SpeciesSIRT1 protein, humanSirtuin 1TOR Serine-Threonine KinasesTumor Necrosis Factor Receptor-Associated Peptides and Proteins

Identifiers

PMID28298952
PMCPMC5337354
OpenAlexW2588910670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.