Evidence map›Paper›PMID 28298912›Full record

ArticleFrontiers in immunology2017

Heterologous Matrix Metalloproteinase Gene Promoter Activity Allows

Fabio Franco Stellari, Francesca Ruscitti, Daniela Pompilio, Francesca Ravanetti, Giulia Tebaldi, Francesca Macchi, Andrea Elizabeth Verna, Gino Villetti, Gaetano Donofrio

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  5. Indocyanine-enhanced mouse model of bleomycin-induced lung fibrosis with hallmarks of progressive emphysema.American journal of physiology. Lung cellular and molecular physiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fabio Franco StellariChiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D , Parma , Italy.
Francesca RuscittiChiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D , Parma , Italy.
Daniela PompilioChiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D, Parma, Italy; Dipartimento di Scienze Medico Veterinarie, Università di Parma, Parma, Italy.
Francesca RavanettiDipartimento di Scienze Medico Veterinarie, Università di Parma , Parma , Italy.
Giulia TebaldiDipartimento di Scienze Medico Veterinarie, Università di Parma , Parma , Italy.
Francesca MacchiDipartimento di Scienze Medico Veterinarie, Università di Parma , Parma , Italy.
Andrea Elizabeth VernaDipartimento di Scienze Medico Veterinarie, Università di Parma , Parma , Italy.
Gino VillettiChiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D , Parma , Italy.
Gaetano DonofrioDipartimento di Scienze Medico Veterinarie, Università di Parma , Parma , Italy.
University of Parma · ITChiesi (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis is a very common interstitial lung disease derived from chronic inflammatory insults, characterized by massive scar tissue deposition that causes the progressive loss of lung function and subsequent death for respiratory failure. Bleomycin is used as the standard agent to induce experimental pulmonary fibrosis in animal models for the study of its pathogenesis. However, to visualize the establishment of lung fibrosis after treatment, the animal sacrifice is necessary. Thus, the aim of this study was to avoid this limitation by using an innovative approach based on a double bleomycin treatment protocol, along with the

Indexed as

bioluminescencebleomycinfluorescent molecular tomographyidiopathic pulmonary fibrosismatrix metalloproteinase-1 promoter

Identifiers

PMID28298912
PMCPMC5331072
OpenAlexW2592494573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.