Evidence map›Paper›PMID 28298894›Full record

ReviewFrontiers in pharmacology2017

Current Situation of Medication Adherence in Hypertension.

Bernard Vrijens, Sotiris Antoniou, Michel Burnier, Alejandro de la Sierra, Massimo Volpe

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 126 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05348538 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Feasibility Study of the Medication Review With Follow up Service for Patients With Polypharmacy in Swiss Community Pharmacies

TypeinterventionalSponsorCenter for Primary Care and Public Health (Unisante), University of Lausanne, SwitzerlandRan2023 to 2024Enrolled162ConditionsChronic DiseaseArmsMedication review with follow up or MaJ? for the acronym in french
NCT07129395 active not recruitingnot on this mapstarted 2023, after this paper: background citation

Optimizing Measurement of Anticoagulation Adherence

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2023 to 2026Enrolled30ConditionsAnticoagulation
3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bernard VrijensWestRock HealthcareVisé, Belgium; Department of Public Health, University of LiègeLiège, Belgium.
Sotiris AntoniouBarts Health NHS Trust London, UK.
Michel BurnierDepartment of Nephrology and Hypertension, University Hospital Lausanne Lausanne, Switzerland.
Alejandro de la SierraInternal Medicine Department, Hospital Mutua Terrassa, University of Barcelona Barcelona, Spain.
Massimo VolpeDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome "La Sapienza"Rome, Italy; IRCCS NeuromedPozzilli, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite increased awareness, poor adherence to treatments for chronic diseases remains a global problem. Adherence issues are common in patients taking antihypertensive therapy and associated with increased risks of coronary and cerebrovascular events. Whilst there has been a gradual trend toward improved control of hypertension, the number of patients with blood pressure values above goal has remained constant. This has both personal and economic consequences. Medication adherence is a multifaceted issue and consists of three components: initiation, implementation, and persistence. A combination of methods is recommended to measure adherence, with electronic monitoring and drug measurement being the most accurate. Pill burden, resulting from free combinations of blood pressure lowering treatments, makes the daily routine of medication taking complex, which can be a barrier to optimal adherence. Single-pill fixed-dose combinations simplify the habit of medication taking and improve medication adherence. Re-packing of medication is also being utilized as a method of improving adherence. This paper presents the outcomes of discussions by a European group of experts on the current situation of medication adherence in hypertension.

Indexed as

adherenceantihypertensiveimplementationinitiationmedicationpersistence

Identifiers

PMID28298894
PMCPMC5331678

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.