ArticleFrontiers in neural circuits2017
Automated Operant Conditioning in the Mouse Home Cage.
Article in Frontiers in neural circuits, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Cortical representation of pitch perception in mice.Communications biology · 2026Article
- The Training Village: an open platform for continuous testing of rodents in cognitive tasks.bioRxiv : the preprint server for biology · 2026Article
- Article
- Cortical Representation of Pitch Perception in Mice.bioRxiv : the preprint server for biology · 2025Article
- Automated head-fixation training system with high levels of animal participation in psychoacoustic tasks.PloS one · 2025Article
- Brief periods of visual deprivation in adults increase performance on auditory tasks.iScience · 2024Article
- Sparse representation of neurons for encoding complex sounds in the auditory cortex.Progress in neurobiology · 2024Article
- Dark exposure reduces high-frequency hearing loss in C57BL/6J mice.bioRxiv : the preprint server for biology · 2024Article
- Long-term training alters response dynamics in the aging auditory cortex.Hearing research · 2024Article
- Challenges and advanced concepts for the assessment of learning and memory function in mice.Frontiers in behavioral neuroscience · 2023Review
- Refinements to rodent head fixation and fluid/food control for neuroscience.Journal of neuroscience methods · 2022Review
- Development of an IntelliCage-based cognitive bias test for mice.Open research Europe · 2022Article
- Roadbumps at the Crossroads of Integrating Behavioral andFrontiers in toxicology · 2022Review
- An open-source device for measuring food intake and operant behavior in rodent home-cages.eLife · 2021Article
- Enduring consequences of perinatal fentanyl exposure in mice.Addiction biology · 2021Article
- Early peripheral activity alters nascent subplate circuits in the auditory cortex.Science advances · 2021Article
- The Stop Signal Task for Measuring Behavioral Inhibition in Mice With Increased Sensitivity and High-Throughput Operation.Frontiers in behavioral neuroscience · 2021Article
- Efficient training of mice on the 5-choice serial reaction time task in an automated rodent training system.Scientific reports · 2020Article
- An automated homecage system for multiwhisker detection and discrimination learning in mice.PloS one · 2020Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Recent advances in neuroimaging and genetics have made mice an advantageous animal model for studying the neurophysiology of sensation, cognition, and locomotion. A key benefit of mice is that they provide a large population of test subjects for behavioral screening. Reflex-based assays of hearing in mice, such as the widely used acoustic startle response, are less accurate than operant conditioning in measuring auditory processing. To date, however, there are few cost-effective options for scalable operant conditioning systems. Here, we describe a new system for automated operant conditioning, the Psibox. It is assembled from low cost parts, designed to fit within typical commercial wire-top cages, and allows large numbers of mice to train independently in their home cages on positive reinforcement tasks. We found that groups of mice trained together learned to accurately detect sounds within 2 weeks of training. In addition, individual mice isolated from groups also showed good task performance. The Psibox facilitates high-throughput testing of sensory, motor, and cognitive skills in mice, and provides a readily available animal population for studies ranging from experience-dependent neural plasticity to rodent models of mental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.