Evidence map›Paper›PMID 28298633›Full record

ArticleScientific reports2017

Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury.

Maxime Rossi, Antoine Thierry, Sandrine Delbauve, Nicolas Preyat, Miguel P Soares, Thierry Roumeguère, Oberdan Leo, Véronique Flamand, Alain Le Moine, Jean-Michel Hougardy

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Antioxidants (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maxime RossiInstitute for Medical Immunology (IMI), Université Libre de Bruxelles, Gosselies, Belgium. mrossi@ulb.ac.be.
Antoine ThierryInstitute for Medical Immunology (IMI), Université Libre de Bruxelles, Gosselies, Belgium.
Sandrine DelbauveInstitute for Medical Immunology (IMI), Université Libre de Bruxelles, Gosselies, Belgium.
Nicolas PreyatLaboratory of Immunobiology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, Gosselies, Belgium.
Miguel P SoaresInstituto Gulbenkian de Ciência, Oeiras, Portugal.ORCID 0000-0002-9314-4833
Thierry RoumeguèreDepartment of Urology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Oberdan LeoInstitute for Medical Immunology (IMI), Université Libre de Bruxelles, Gosselies, Belgium.
Véronique FlamandInstitute for Medical Immunology (IMI), Université Libre de Bruxelles, Gosselies, Belgium.
Alain Le MoineInstitute for Medical Immunology (IMI), Université Libre de Bruxelles, Gosselies, Belgium.
Jean-Michel HougardyInstitute for Medical Immunology (IMI), Université Libre de Bruxelles, Gosselies, Belgium. Jean-Michel.Hougardy@erasme.ulb.ac.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal ischemia-reperfusion injury (IRI) is a major risk factor for delayed graft function in renal transplantation. Compelling evidence exists that the stress-responsive enzyme, heme oxygenase-1 (HO-1) mediates protection against IRI. However, the role of myeloid HO-1 during IRI remains poorly characterized. Mice with myeloid-restricted deletion of HO-1 (HO-1

Indexed as

AnimalsCells, CulturedDisease Models, AnimalGene Knockout TechniquesHeme Oxygenase-1HeminKidney DiseasesMaleMembrane ProteinsMiceMyeloid CellsOxidative StressReperfusion InjuryUp-RegulationHeme Oxygenase-1HeminHmox1 protein, mouseMembrane Proteins

Identifiers

PMID28298633
PMCPMC5428056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.