SynthesisBiology letters2017
Dietary restriction increases variability in longevity.
Synthesis in Biology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Effects of Leaf Herbivory on Floral Trait Correlations and Scent Composition in Asclepias syriaca.Journal of chemical ecology · 2025Article
- The Hunger Games as the Key to Happily Ever After?The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Review
- Estimating Genetic Variance in Life-Span Response to Diet: Insights From Statistical Simulation.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Global associations between macronutrient supply and age-specific mortality.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.Aging cell · 2020Article
- Dietary macronutrient content, age-specific mortality and lifespan.Proceedings. Biological sciences · 2019Article
- Ageing with a silver-spoon: A meta-analysis of the effect of developmental environment on senescence.Evolution letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutritional environments, particularly those experienced during early life, are hypothesized to affect longevity. A recent cross-taxa meta-analysis found that, depending upon circumstance, average longevity may be increased or decreased by early-life dietary restriction. Unstudied are the effects of diet during development on among-individual variance in longevity. Here, we address this issue using emerging methods for meta-analysis of variance. We found that, in general, standard deviation (s.d.) in longevity is around 8% higher under early-life dietary restriction than a standard diet. The effects became especially profound when dietary insults were experienced prenatally (s.d. increased by 29%) and/or extended into adulthood (s.d. increased by 36.6%). Early-life dietary restriction may generate variance in longevity as a result of increased variance in resource acquisition or allocation, but the mechanisms underlying these largely overlooked patterns clearly warrant elucidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.