Evidence map›Paper›PMID 28298549›Full record

ArticleNeurology2017

Diverging white matter trajectories in children after traumatic brain injury: The RAPBI study.

Emily L Dennis, Faisal Rashid, Monica U Ellis, Talin Babikian, Roza M Vlasova, Julio E Villalon-Reina, Yan Jin, Alexander Olsen, Richard Mink, Christopher Babbitt and 4 more

Abstract read
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In one paragraph

Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Neuroimaging of the Injured Pediatric Brain: Methods and New Lessons.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018
    Review
  16. Article
  17. Article
  18. A Comparative Study of Automatic Approaches for Preclinical MRI-based Brain Segmentation in the Developing Rat.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2018
    Article
  19. Article
  20. Diffusion MRI in pediatric brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Emily L DennisFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA. emily.dennis@ini.usc.edu.
Faisal RashidFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Monica U EllisFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Talin BabikianFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Roza M VlasovaFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Julio E Villalon-ReinaFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Yan JinFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Alexander OlsenFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Richard MinkFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Christopher BabbittFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Jeffrey JohnsonFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Christopher C GizaFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Paul M ThompsonFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.
Robert F AsarnowFrom the Imaging Genetics Center (E.L.D., F.R., J.E.V.-R., Y.J., P.M.T.), Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior (M.U.E., T.B., A.O., R.F.A.), Department of Psychology (R.F.A.), and Brain Research Institute (R.F.A.), UCLA, Los Angeles; Fuller Theological Seminary School of Psychology (M.U.E.), Pasadena; CIBORG Laboratory (R.M.V.), Department of Radiology, Children's Hospital Los Angeles, CA; Department of Psychology (A.O.), Norwegian University of Science and Technology; Department of Physical Medicine and Rehabilitation (A.O.), St. Olavs Hospital, Trondheim University Hospital, Norway; Harbor-UCLA Medical Center and Los Angeles BioMedical Research Institute (R.M.), Department of Pediatrics, Torrance; Miller Children's Hospital (C.B.), Long Beach; Department of Pediatrics (J.J.), LAC+USC Medical Center; Department of Neurosurgery and Division of Pediatric Neurology, UCLA Brain Injury Research Center (C.C.G.), Mattel Children's Hospital; and Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology (P.M.T.), USC, Los Angeles, CA.

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Using glutamatergic pharmacotherapy to optimize TBI recoveryR01NS027544 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HOVDA, DAVID A · 1990 to 2017
$3.8M
Reconnection of Neural Networks and Cognitive Recovery after Pediatric TBIR01HD061504 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASARNOW, ROBERT F · 2010 to 2014
$2.9M
HARDI Mapping of Disease Effects on the BrainR01EB008432 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2009 to 2012
$2.6M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Predicting Brain Changes in HIV/AIDSR01NS080655 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAVIA, BRADFORD, THOMPSON, PAUL M · 2012 to 2015
$2.3M
Longitudinal Tracking of Traumatic Brain Injury: Advanced ConnectomicsK99NS096116 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DENNIS, EMILY LARSEN · 2016 to 2017
$176k
NIA NIH HHS R01 AG040060NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB008432NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD061504NINDS NIH HHS K99 NS096116NINDS NIH HHS R01 NS027544NINDS NIH HHS R01 NS080655
6 · The paper itself

Abstract

objectiveTo examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period.

methodsWe studied 21 children (16 M/5 F) with msTBI, assessed 2-5 months postinjury and again 13-19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure. At the first time point, half of the patients with TBI had significantly slower IHTT (TBI-slow-IHTT, n = 11) and half were in the normal range (TBI-normal-IHTT, n = 10).

resultsThe TBI-normal-IHTT group did not differ significantly from healthy controls, either in WM organization in the chronic phase or in the longitudinal trajectory of WM organization between the 2 evaluations. In contrast, the WM organization of the TBI-slow-IHTT group was significantly lower than in healthy controls across a large portion of the WM. Longitudinal analyses showed that the TBI-slow-IHTT group experienced a progressive decline between the 2 evaluations in WM organization throughout the brain.

conclusionsWe present preliminary evidence suggesting a potential biomarker that identifies a subset of patients with impaired callosal organization in the first months postinjury who subsequently experience widespread continuing and progressive degeneration in the first year postinjury.

Indexed as

AdolescentBrain Injuries, TraumaticCase-Control StudiesChildCognition DisordersCorpus CallosumDiffusion Tensor ImagingElectroencephalographyEvoked PotentialsFemaleGlasgow Coma ScaleHumansLongitudinal StudiesMaleNeuropsychological TestsWhite Matter

Identifiers

PMID28298549
PMCPMC5386434

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