Evidence map›Paper›PMID 28298447›Full record

ArticleThe Journal of biological chemistry2017

Structural and functional characterization of

Hyunook Kang, Injin Bang, Kyeong Sik Jin, Boyun Lee, Junho Lee, Xiangqiang Shao, Jonathon A Heier, Adam V Kwiatkowski, W James Nelson, Jeff Hardin and 2 more

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Single-molecule force spectroscopy reveals intra- and intermolecular interactions ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Game of Tissues: How the Epidermis ThronesJournal of developmental biology · 2020
    Review
  13. The adhesion modulation domain ofMolecular biology of the cell · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hyunook KangFrom the School of Biological Sciences, Seoul National University, Seoul 08826, South Korea.
Injin BangFrom the School of Biological Sciences, Seoul National University, Seoul 08826, South Korea.
Kyeong Sik Jinthe Pohang Accelerator Laboratory, Pohang, Gyeongbuk 37673, South Korea.
Boyun Leethe Department of Biophysics and Chemical Biology and.
Junho LeeFrom the School of Biological Sciences, Seoul National University, Seoul 08826, South Korea.
Xiangqiang Shaothe Department of Zoology and Program in Genetics, University of Wisconsin, Madison, Wisconsin 53706.
Jonathon A Heierthe Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, and.
Adam V Kwiatkowskithe Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, and.
W James Nelsonthe Departments of Biology.
Jeff Hardinthe Department of Zoology and Program in Genetics, University of Wisconsin, Madison, Wisconsin 53706.
William I WeisMolecular and Cellular Physiology, and.
Hee-Jung ChoiFrom the School of Biological Sciences, Seoul National University, Seoul 08826, South Korea, choihj@snu.ac.kr.

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
TRAINING & OUTREACH COREP50GM107615 · NIGMS · STANFORD UNIVERSITY · PI FERRELL, JAMES E. · 2013 to 2017
$10.9M
Assemby , dynamics and evolution of cell-cell and cell-matrix adhesionsU01GM094663 · NIGMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI LIDDINGTON, ROBERT COLIN · 2010 to 2014
$6.4M
Tension-dependent regulation of alpha-catenin during morphogenesis in C. elegansR01GM058038 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HARDIN, JEFFREY D · 1998 to 2021
$6.2M
Alpha-catenin function in cardiomyocyte adhesion and cytoskeletal organizationR01HL127711 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KWIATKOWSKI, ADAM VINCENT · 2016 to 2024
$3.5M
Cell-Cell Junctions and Epithelial HomeostasisR35GM118064 · NIGMS · STANFORD UNIVERSITY · PI STEARNS, TIM · 2016 to 2018
$2.6M
Understanding force-dependent binding of alpha-catenin to actinR01GM114462 · NIGMS · STANFORD UNIVERSITY · PI DUNN, ALEXANDER R, WEIS, WILLIAM I · 2015 to 2018
$1.2M
NHLBI NIH HHS R01 HL127711NIGMS NIH HHS P41 GM103393NIGMS NIH HHS P50 GM107615NIGMS NIH HHS R01 GM058038NIGMS NIH HHS R01 GM114462NIGMS NIH HHS R35 GM118064NIGMS NIH HHS U01 GM094663
6 · The paper itself

Abstract

Intercellular epithelial junctions formed by classical cadherins, β-catenin, and the actin-binding protein α-catenin link the actin cytoskeletons of adjacent cells into a structural continuum. These assemblies transmit forces through the tissue and respond to intracellular and extracellular signals. However, the mechanisms of junctional assembly and regulation are poorly understood. Studies of cadherin-catenin assembly in a number of metazoans have revealed both similarities and unexpected differences in the biochemical properties of the cadherin·catenin complex that likely reflect the developmental and environmental requirements of different tissues and organisms. Here, we report the structural and biochemical characterization of HMP-1, the

Indexed as

ActinsAllosteric Sitealpha CateninAnimalsbeta CateninCadherinsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell AdhesionCrystallography, X-RayCytoskeletal ProteinsGlutathione TransferaseMolecular Dynamics SimulationProtein BindingProtein DomainsRabbitsActinsalpha Cateninbeta CateninCadherinsCaenorhabditis elegans ProteinsCytoskeletal ProteinsGlutathione TransferaseHMP-1 protein, C elegansHMP-2 protein, C eleganshmr-1 protein, C elegansVinculinactinCaenorhabditis elegans (C. elegans)cell adhesionfour helix bundleHMP-1HMP-2small-angle X-ray scattering (SAXS)X-ray crystallographyα-catenin (a-catenin)

Identifiers

PMID28298447
PMCPMC5409474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.