Evidence map›Paper›PMID 28298445›Full record

ArticleThe Journal of biological chemistry2017

The structure and function of

Eric D Hoffer, Stacey J Miles, Christine M Dunham

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Recent Characterization of Key Proteins to Combat Tuberculosis.Advances in experimental medicine and biology · 2026
    Review
  5. Long Dynamic β1-β2 Loops inInternational journal of molecular sciences · 2024
    Article
  6. Identification of Genes Encoded Toxin-Antitoxin System inInfectious disorders drug targets · 2024
    Article
  7. Article
  8. Conserved Amino Acid Moieties ofFrontiers in microbiology · 2021
    Article
  9. Article
  10. mRNA InterferaseToxins · 2020
    Article
  11. Review
  12. Article
  13. Article
  14. Structural analyses of the MazEF4 toxin-antitoxin pair inThe Journal of biological chemistry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Eric D HofferFrom the Biochemistry, Cell and Developmental Biology Program, Graduate Division of Biological and Biomedical Sciences and.
Stacey J Milesthe Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322.
Christine M Dunhamthe Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 christine.m.dunham@emory.edu.ORCID 0000-0002-8821-688X
Emory University · US

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
NCRR NIH HHS S10 RR029205NIGMS NIH HHS P41 GM103403
6 · The paper itself

Abstract

Toxin-antitoxin systems are ubiquitous in prokaryotic and archaeal genomes and regulate growth in response to stress.

Indexed as

AntitoxinsBacterial ProteinsBacterial ToxinsCrystallography, X-RayDNA-Binding ProteinsEndoribonucleasesEscherichia coliEscherichia coli ProteinsMycobacterium tuberculosisNucleic Acid ConformationOperonProtein MultimerizationProtein Structure, SecondaryRNA, MessengerRNA, Ribosomal, 23SSubstrate SpecificityAntitoxinsBacterial ProteinsBacterial ToxinsDNA-Binding ProteinsEndoribonucleasesEscherichia coli ProteinsMazF protein, E coliMazF protein, Mycobacterium tuberculosisRNA, MessengerRNA, Ribosomal, 23Sbacterial toxinendoribonucleaseprotein synthesisribosomal ribonucleic acid (rRNA) (ribosomal RNA)ribosomeX-ray crystallography

Identifiers

PMID28298445
PMCPMC5427253
OpenAlexW2599459400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.