Evidence map›Paper›PMID 28298362›Full record

ArticleAmerican journal of physiology. Renal physiology2017

Negative regulation of Smad1 pathway and collagen IV expression by store-operated Ca

Peiwen Wu, Yuezhong Ren, Yuhong Ma, Yanxia Wang, Hui Jiang, Sarika Chaudhari, Mark E Davis, Jonathan E Zuckerman, Rong Ma

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. I-mfa, Mesangial Cell TRPC1 Channel, and Regulation of GFR.Journal of the American Society of Nephrology : JASN · 2025
    Article
  2. Review
  3. Non-voltage-gated CaAmerican journal of physiology. Renal physiology · 2024
    Review
  4. Store-operated CaExperimental biology and medicine (Maywood, N.J.) · 2023
    Review
  5. Review
  6. Review
  7. Enhanced Orai1-mediated store-operated CaThe Journal of biological chemistry · 2022
    Article
  8. Review
  9. Store-operated calcium entry: Pivotal roles in renal physiology and pathophysiology.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  10. Stimulation of ORAI1 expression, store-operated CaPflugers Archiv : European journal of physiology · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Peiwen WuInstitute for Cardiovascular and Metabolic Disease, University of North Texas Health Science Center, Fort Worth, Texas.
Yuezhong RenInstitute for Cardiovascular and Metabolic Disease, University of North Texas Health Science Center, Fort Worth, Texas.
Yuhong MaInstitute for Cardiovascular and Metabolic Disease, University of North Texas Health Science Center, Fort Worth, Texas.
Yanxia WangInstitute for Cardiovascular and Metabolic Disease, University of North Texas Health Science Center, Fort Worth, Texas.
Hui JiangInstitute for Cardiovascular and Metabolic Disease, University of North Texas Health Science Center, Fort Worth, Texas.
Sarika ChaudhariInstitute for Cardiovascular and Metabolic Disease, University of North Texas Health Science Center, Fort Worth, Texas.
Mark E DavisChemical Engineering, California Institute of Technology, Pasadena, California.
Jonathan E ZuckermanChemical Engineering, California Institute of Technology, Pasadena, California.
Rong MaInstitute for Cardiovascular and Metabolic Disease, University of North Texas Health Science Center, Fort Worth, Texas; rong.ma@unthsc.edu.
University of North Texas · USCalifornia Institute of Technology · USUniversity of North Texas Health Science Center · USSecond Affiliated Hospital of Zhejiang University · CNWannan Medical College · CN

Funding

NADPH oxidases-derived ROS downregulate TRPC6 in mesangial cells in diabetesR01DK079968 · NIDDK · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI MA, RONG · 2009 to 2013
$1.5M
NIDDK NIH HHS R01 DK079968
6 · The paper itself

Abstract

Collagen IV (Col IV) is a major component of expanded glomerular extracellular matrix in diabetic nephropathy and Smad1 is a key molecule regulating Col IV expression in mesangial cells (MCs). The present study was conducted to determine if Smad1 pathway and Col IV protein abundance were regulated by store-operated Ca

Indexed as

Calcium SignalingAngiotensin IIAnimalsCalcium Channel BlockersCells, CulturedCollagen Type IVGene Expression RegulationGlucoseHumansMesangial CellsMiceORAI1 ProteinPhosphorylationRNA InterferenceSmad1 ProteinTime FactorsAngiotensin IICalcium Channel BlockersCollagen Type IVGlucoseORAI1 ProteinOrai1 protein, mouseSmad1 ProteinSMAD1 protein, humanSmad1 protein, mouseTGFB1 protein, humanTransforming Growth Factor beta1extracellular matrixstore-operated calcium entry

Identifiers

PMID28298362
PMCPMC5495888
OpenAlexW2599270378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.