ArticleJournal of neurophysiology2017
Ion diffusion may introduce spurious current sources in current-source density (CSD) analysis.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Neurophysiological mechanisms of error monitoring in human and non-human primates.Nature reviews. Neuroscience · 2023Review
- Computing Extracellular Electric Potentials from Neuronal Simulations.Advances in experimental medicine and biology · 2022Article
- An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.PLoS computational biology · 2021Article
- An electrodiffusive, ion conserving Pinsky-Rinzel model with homeostatic mechanisms.PLoS computational biology · 2020Article
- Finite Element Simulation of Ionic Electrodiffusion in Cellular Geometries.Frontiers in neuroinformatics · 2020Article
- V1 microcircuit dynamics: altered signal propagation suggests intracortical origins for adaptation in response to visual repetition.Journal of neurophysiology · 2019Article
- A Kirchhoff-Nernst-Planck framework for modeling large scale extracellular electrodiffusion surrounding morphologically detailed neurons.PLoS computational biology · 2018Article
- Coding of self-motion-induced and self-independent visual motion in the rat dorsomedial striatum.PLoS biology · 2018Article
- Heterogeneous Origins of Human Sleep Spindles in Different Cortical Layers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Brains are Probabilistic, Electrophysiologically Intricate and Triune: A Biased- Random Walk Perspective on Computational Neuroscience.International journal of psychological researchArticle
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5 authors.
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Abstract
Current-source density (CSD) analysis is a well-established method for analyzing recorded local field potentials (LFPs), that is, the low-frequency part of extracellular potentials. Standard CSD theory is based on the assumption that all extracellular currents are purely ohmic, and thus neglects the possible impact from ionic diffusion on recorded potentials. However, it has previously been shown that in physiological conditions with large ion-concentration gradients, diffusive currents can evoke slow shifts in extracellular potentials. Using computer simulations, we here show that diffusion-evoked potential shifts can introduce errors in standard CSD analysis, and can lead to prediction of spurious current sources. Further, we here show that the diffusion-evoked prediction errors can be removed by using an improved CSD estimator which accounts for concentration-dependent effects.
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