Evidence map›Paper›PMID 28298301›Full record

ArticleJournal of neurophysiology2017

In vivo optogenetic activation of Na

Megan L Uhelski, Daniel J Bruce, Philippe Séguéla, George L Wilcox, Donald A Simone

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. New era of optogenetics: from the central to peripheral nervous system.Critical reviews in biochemistry and molecular biology · 2020
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Megan L UhelskiDepartment of Diagnostic & Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota.
Daniel J BruceDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota.
Philippe SéguélaMontreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
George L WilcoxDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota.
Donald A SimoneDepartment of Diagnostic & Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota; simon003@umn.edu.
University of Minnesota · USMontreal Neurological Institute and Hospital · CA

Funding

Training in PharmacoNeuroImmune Substance Abuse ResearchT32DA007097 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MOLITOR, THOMAS WILLIAM · 1985 to 2021
$13.1M
CIHR MOP-130239NIDA NIH HHS T32 DA007097
6 · The paper itself

Abstract

Optogenetic methods that utilize expression of the light-sensitive protein channelrhodopsin-2 (ChR2) in neurons have enabled selective activation of specific subtypes or groups of neurons to determine their functions. Using a transgenic mouse model in which neurons natively expressing Na

Indexed as

Action PotentialsAnimalsChannelrhodopsinsFemaleHindlimbMaleMice, TransgenicNAV1.8 Voltage-Gated Sodium ChannelNerve Fibers, UnmyelinatedNociceptionNociceptorsOptogeneticsPhysical StimulationSkinChannelrhodopsinsNAV1.8 Voltage-Gated Sodium ChannelC-fiberchannelrhodopsin2electrophysiologyperipheral neurontibial nerve

Identifiers

PMID28298301
PMCPMC5454474
OpenAlexW2616221807

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.