Evidence map›Paper›PMID 28298293›Full record

SynthesisJournal of lipid research2017

Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations.

Yao Hu, Toshiko Tanaka, Jingwen Zhu, Weihua Guan, Jason H Y Wu, Bruce M Psaty, Barbara McKnight, Irena B King, Qi Sun, Melissa Richard and 23 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Use of Mendelian Randomization to Unveil Metabolic Markers inJournal of Korean medical science · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 19 institutions in 6 countries.

Yao HuThe Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD.
Jingwen ZhuThe Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China.
Weihua GuanDivision of Biostatistics University of Minnesota, Minneapolis, MN.
Jason H Y WuGeorge Institute for Global Health, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.
Barbara McKnightDepartment of Biostatistics, University of Washington, Seattle, WA.
Irena B KingDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM.
Qi SunChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Melissa RichardInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.
Alexis C Frazier-WoodUSDA Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Edmond K KabagambeDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Paul N HopkinsDepartment of Internal Medicine, University of Utah, Salt Lake City, UT.
Jose M OrdovasNutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.
Donna K ArnettDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.
Yii-Der I ChenInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Shuang LiangDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
David S SiscovickCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX.
Frank B HuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Eric B RimmChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Majken K JensenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.
Dariush MozaffarianFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA.
Lyn M SteffenDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Andrew P MorrisGenetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom.
Huaixing LiThe Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China xlin@sibs.ac.cn lihx@sibs.ac.cn.
Xu LinThe Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China xlin@sibs.ac.cn lihx@sibs.ac.cn.
Harvard University · USUniversity of Minnesota · USUniversity of Washington · USChinese Academy of Sciences · CNNational Institute on Aging · USShanghai Institutes for Biological Sciences · CNThe University of Texas Health Science Center at Houston · USTufts University · USUniversity of Virginia · USAzienda Sanitaria di Firenze · ITCentre for Human Genetics · GBChildren's Nutrition Research Center at Baylor College of Medicine · USNew York Academy of Medicine · USThe Lundquist Institute · USUniversity of Alabama at Birmingham · USUniversity of New Mexico · USUniversity of Sydney · AUUniversity of Utah · USVanderbilt University Medical Center · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
A Center for GEI Association StudiesU01HG004424 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2010
$21.4M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
Variation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4M
Genetic and Environmental Determinants of TriglyceridesU01HL072524 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 2002 to 2008
$11.9M
NCATS NIH HHS UL1 TR000124NCI NIH HHS P01 CA055075NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NCRR NIH HHS UL1 RR024156NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004729NHGRI NIH HHS U01 HG008657NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R00 HL098459NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL054776NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL060712NHLBI NIH HHS R01 HL084099NHLBI NIH HHS R01 HL085710NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL072524NHLBI NIH HHS U01 HL080295NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491NIMHD NIH HHS R01 MD009164
6 · The paper itself

Abstract

MUFAs are unsaturated FAs with one double bond and are derived from endogenous synthesis and dietary intake. Accumulating evidence has suggested that plasma and erythrocyte MUFA levels are associated with cardiometabolic disorders, including CVD, T2D, and metabolic syndrome (MS). Previous genome-wide association studies (GWASs) have identified seven loci for plasma and erythrocyte palmitoleic and oleic acid levels in populations of European origin. To identify additional MUFA-associated loci and the potential functional variant at each locus, we performed ethnic-specific GWAS meta-analyses and trans-ethnic meta-analyses in more than 15,000 participants of Chinese and European ancestry. We identified novel genome-wide significant associations for vaccenic acid at

Indexed as

Asian PeopleChromosome MappingDelta-5 Fatty Acid DesaturaseFatty Acids, MonounsaturatedGenetic LociGenome-Wide Association StudyHumansWhite PeopleDelta-5 Fatty Acid DesaturaseFADS1 protein, humanFatty Acids, Monounsaturatedfatty acid/biosynthesisfatty acid/desaturasesfatty acid/metabolismgeneticsmonounsaturated fatty acid

Identifiers

PMID28298293
PMCPMC5408616
OpenAlexW2600906008

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.