Evidence map›Paper›PMID 28298266›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2017

Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models.

Lewis P Rubin, A Catharine Ross, Charles B Stephensen, Torsten Bohn, Sherry A Tanumihardjo

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Lewis P RubinTexas Tech Health Sciences Center El Paso, El Paso, TX.
A Catharine RossPennsylvannia State University, State College, PA.
Charles B StephensenUSDA Western Human Nutrition Research Center, Davis, CA.
Torsten BohnLuxembourg Institute of Health, Population Health Department, Strassen, Luxembourg; and.
Sherry A TanumihardjoDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI sherry@nutrisci.wisc.edu.
Luxembourg Institute of Health · LUPennsylvania State University · USTexas Tech University · USUniversity of Wisconsin System · USWestern Human Nutrition Research Center · US

Funding

VITAMIN A NUTRITIONAL STATUS AND IMMUNE FUNCTIONR01DK041479 · NIDDK · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI ROSS, A. CATHARINE · 1989 to 2015
$4.0M
Vitamin A Supplementation and Retinol Metabolism in the Neonatal PeriodR01HD066982 · NICHD · PENNSYLVANIA STATE UNIVERSITY, THE · PI ROSS, A. CATHARINE · 2010 to 2019
$2.9M
NICHD NIH HHS R01 HD066982NIDDK NIH HHS R01 DK041479
6 · The paper itself

Abstract

The association between inflammation and vitamin A (VA) metabolism and status assessment has been documented in multiple studies with animals and humans. The relation between inflammation and carotenoid status is less clear. Nonetheless, it is well known that carotenoids are associated with certain health benefits. Understanding these relations is key to improving health outcomes and mortality risk in infants and young children. Hyporetinolemia, i.e., low serum retinol concentrations, occurs during inflammation, and this can lead to the misdiagnosis of VA deficiency. On the other hand, inflammation causes impaired VA absorption and urinary losses that can precipitate VA deficiency in at-risk groups of children. Many epidemiologic studies have suggested that high dietary carotenoid intake and elevated plasma concentrations are correlated with a decreased risk of several chronic diseases; however, large-scale carotenoid supplementation trials have been unable to confirm the health benefits and in some cases resulted in controversial results. However, it has been documented that dietary carotenoids and retinoids play important roles in innate and acquired immunity and in the body's response to inflammation. Although animal models have been useful in investigating retinoid effects on developmental immunity, it is more challenging to tease out the effects of carotenoids because of differences in the absorption, kinetics, and metabolism between humans and animal models. The current understanding of the relations between inflammation and retinoid and carotenoid metabolism and status are the topics of this review.

Indexed as

AnimalsCarotenoidsDisease Models, AnimalDose-Response Relationship, DrugHumansInflammationVitamin AVitamin A DeficiencyCarotenoidsVitamin Abiomarkerscytokinesinfectionretinolretinol-binding proteinsequestrationurinary loss

Identifiers

PMID28298266
PMCPMC5347109
OpenAlexW2602301706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.