Evidence map›Paper›PMID 28298187›Full record

Trial reportBMC cancer2017

iCanADAPT Early protocol: randomised controlled trial (RCT) of clinician supervised transdiagnostic internet-delivered cognitive behaviour therapy (iCBT) for depression and/or anxiety in early stage cancer survivors -vs- treatment as usual.

M J Murphy, J M Newby, P Butow, L Kirsten, K Allison, S Loughnan, M A Price, J Shaw, H Shepherd, J Smith and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial

In one paragraph

Trial report in BMC cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04287218 (A Randomized Controlled Trial Comparing the Efficacy of Therapist Guided Internet-delivered Cognitive Therapy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

1.8field-weighted citation impact, top 15% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04287218 nacompletednot on this mapstarted 2023, after this paper: background citation

A Randomized Controlled Trial Comparing the Efficacy of Therapist Guided Internet-delivered Cognitive Therapy (TG-iConquerFear) With Augmented Treatment as Usual in Reducing Fear of Cancer Recurrence in Danish Colorectal Cancer Survivors

TypeinterventionalSponsorVejle HospitalRan2023 to 2026Enrolled95ConditionsFear of Cancer Recurrence, Colorectal Cancer, Anxiety, Health AnxietyArmsTG-iConquerFear, aTAU

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

M J MurphyClinical Research Unit for Anxiety and Depression (CRUfAD), UNSW School of Psychiatry at St Vincent's Hospital, Level 4, O'Brien Centre, St Vincent's Hospital, 394 Victoria Street, Sydney, NSW, 2010, Australia. michael.murphy@unsw.edu.au.

J M NewbyClinical Research Unit for Anxiety and Depression (CRUfAD), UNSW School of Psychiatry at St Vincent's Hospital, Level 4, O'Brien Centre, St Vincent's Hospital, 394 Victoria Street, Sydney, NSW, 2010, Australia.

P ButowPsycho-oncology Co-operative Research Group (PoCoG), School of Psychology, Level 6, Chris O'Brien Lifehouse (C39Z), The University of Sydney, Sydney, NSW, 2006, Australia.

L KirstenNepean Cancer Care Centre, Sydney West Cancer Network, Kingswood, NSW, 2747, Australia.

K AllisonPsycho-oncology Co-operative Research Group (PoCoG), School of Psychology, Level 6, Chris O'Brien Lifehouse (C39Z), The University of Sydney, Sydney, NSW, 2006, Australia.

S LoughnanClinical Research Unit for Anxiety and Depression (CRUfAD), UNSW School of Psychiatry at St Vincent's Hospital, Level 4, O'Brien Centre, St Vincent's Hospital, 394 Victoria Street, Sydney, NSW, 2010, Australia.

M A PricePsycho-oncology Co-operative Research Group (PoCoG), School of Psychology, Level 6, Chris O'Brien Lifehouse (C39Z), The University of Sydney, Sydney, NSW, 2006, Australia.

J ShawPsycho-oncology Co-operative Research Group (PoCoG), School of Psychology, Level 6, Chris O'Brien Lifehouse (C39Z), The University of Sydney, Sydney, NSW, 2006, Australia.

H ShepherdPsycho-oncology Co-operative Research Group (PoCoG), School of Psychology, Level 6, Chris O'Brien Lifehouse (C39Z), The University of Sydney, Sydney, NSW, 2006, Australia.

J SmithPsycho-oncology Co-operative Research Group (PoCoG), School of Psychology, Level 6, Chris O'Brien Lifehouse (C39Z), The University of Sydney, Sydney, NSW, 2006, Australia.

G AndrewsClinical Research Unit for Anxiety and Depression (CRUfAD), UNSW School of Psychiatry at St Vincent's Hospital, Level 4, O'Brien Centre, St Vincent's Hospital, 394 Victoria Street, Sydney, NSW, 2010, Australia.

Chris O’Brien Lifehouse · AUSt Vincent's Hospital · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis RCT with two parallel arms will evaluate the efficacy of an internet-delivered transdiagnostic cognitive behavioural therapy (iCBT) intervention for the treatment of clinical depression and/or anxiety in early stage cancer survivors. METHODS/

designEarly stage cancer survivors will be recruited via the research arm of a not-for-profit clinical research unit and randomised to an intervention (iCBT) group or a 'treatment as usual' (TAU) control group. The minimum sample size for each group is 45 people (assuming effect size > 0.6, power of 80%, and alpha at .05), but 10% more will be recruited to account for attrition. A solitary or cumulative diagnosis(es) of Major Depressive Episode (current), Generalised Anxiety Disorder, Illness Anxiety Disorder, Panic Disorder, Agoraphobia, and/or Adjustment disorder will be determined using modules from the Anxiety Disorders Interview Schedule for DSM-5. Depression and anxiety levels with be measured via the total score of the Hospital Anxiety and Depression scale (HADS-T), the primary outcome measure. Secondary measures will include the Kessler 10 to measure general distress, the Fear of Cancer Recurrence Inventory (FCRI) to measure the specific fear of cancer recurrence and the Functional Assessment of Cancer Therapy, General Version 4 (FACT-G) for self-report of physical, social, emotional and functional well-being. iCBT participants will complete the measures before lessons 1 and 5, at post-treatment and at 3-month follow-up. The TAU group will complete similar measures at weeks 1, 8 and 16 of the waiting period. Program efficacy will be determined using intent-to-treat mixed models. Maintenance of gains will be assessed at 3-month follow-up. Mediation analyses using PROCESS will be used to examine the association between change in depressive and anxious symptoms over time and changes in FCRI and FACT-G QOL in separate analysis. DISCUSSION: This is the first RCT looking at iCBT specifically for clinical depression and/or anxiety in a cancer population. Findings will help to direct the role of iCBT in streamlined psycho-social care pathways.

trial registrationAustralian New Zealand Clinical Trials Registry: ACTRN12616000231448, registered 19

Indexed as

Anxiety DisordersAustraliaCancer SurvivorsCognitive Behavioral TherapyDepressionFemaleHumansInternetMalePsychometricsResearch DesignSample SizeSelf ReportTreatment OutcomeAnxietyCancerDepressionInternet cognitive behavioural therapyProtocolRandomised controlled trial

Identifiers

PMID28298187

DOI10.1186/s12885-017-3182-z

PMCPMC5353884

OpenAlexW2597701401

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

NCT04287218ClinicalTrials.gov

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.