Trial reportJournal of neurosurgery2018
Carotid atherosclerotic plaque instability and cognition determined by ultrasound-measured plaque strain in asymptomatic patients with significant stenosis.
Trial report in Journal of neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Structural Stability of Carotid Plaque and Symptomatology
Stroke Prevention in the Wisconsin Native American Population
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- A bibliometric analysis of research on cognitive function and carotid atherosclerosis: global trends and hotspots.Frontiers in neurology · 2025Pooled it
- Self-supervised ultrasound B-mode strain elastography using SMURF.Ultrasonics · 2026Article
- Lagrangian deformation tracking for strain imaging.Progress in biomedical engineering (Bristol, England) · 2026Review
- Novel Cerebrovascular Disease Blood Biomarkers Identified by Targeted Proteomics in a High-Risk Native American Population.World neurosurgery · 2026Article
- Comparative Analysis of Common Carotid Artery Intima-Media Thickness and Lagrangian Wall Strain in Relation to Cardiovascular Risk Factors Using Ultrasound.Ultrasound in medicine & biology · 2025Article
- Clinical Risk Factors for Stroke and Associations with Microembolic Signals on Transcranial Doppler.Journal for vascular ultrasound : JVU · 2025Article
- Preoperative brain volume loss is associated with postoperative delirium in advanced heart failure patients supported by left ventricular assist device.Scientific reports · 2025Article
- Multimodal fusion model for diagnosing mild cognitive impairment in unilateral middle cerebral artery steno-occlusive disease.Frontiers in aging neuroscience · 2025Article
- Unstable Plaque is a Treatable Cause of Cognitive Decline.Medical hypotheses · 2024Article
- Lumen segmentation using a Mask R-CNN in carotid arteries with stenotic atherosclerotic plaque.Ultrasonics · 2024Article
- Association between atherosclerosis and the development of multi-organ pathologies.SAGE open medicine · 2024Review
- Unsupervised deep learning-based displacement estimation for vascular elasticity imaging applications.Physics in medicine and biology · 2023Article
- New Technologies in the Assessment of Carotid Stenosis: Beyond the Color-Doppler Ultrasound-High Frame Rate Vector-Flow and 3D Arterial Analysis Ultrasound.Diagnostics (Basel, Switzerland) · 2023Review
- Magnetic resonance imaging reveals microemboli-mediated pathological changes in brain microstructure in diabetic rats: relevance to vascular cognitive impairment/dementia.Clinical science (London, England : 1979) · 2022Article
- Bioinformatic identification of potential biomarkers and therapeutic targets in carotid atherosclerosis and vascular dementia.Frontiers in neurology · 2022Article
- Feasibility of longitudinal monitoring of atherosclerosis with pulse wave imaging in a swine model.Physiological measurement · 2021Article
- Impact of carotid stenosis on cerebral hemodynamic failure and cognitive impairment progression: a narrative review.Annals of translational medicine · 2021Review
- Atherosclerosis: The Culprit and Co-victim of Vascular Dementia.Frontiers in neuroscience · 2021Review
- Diabetic rats are more susceptible to cognitive decline in a model of microemboli-mediated vascular contributions to cognitive impairment and dementia.Brain research · 2020Article
- Carotid Plaque Strain Indices Were Correlated With Cognitive Performance in a Cohort With Advanced Atherosclerosis, and Traditional Doppler Measures Showed no Association.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
OBJECTIVE This article describes the use of ultrasound measurements of physical strain within carotid atherosclerotic plaques as a measure of instability and the potential for vascular cognitive decline, microemboli, and white matter changes. METHODS Asymptomatic patients with significant (> 60%) carotid artery stenosis were studied for dynamic measures of plaque instability, presence of microemboli, white matter changes, and vascular cognitive decline in comparison with normative controls and premorbid state. RESULTS Although classically asymptomatic, these patients showed vascular cognitive decline. The degree of strain instability measured within the atherosclerotic plaque directly predicted vascular cognitive decline in these patients thought previously to be asymptomatic according to classic criteria. Furthermore, 26% of patients showed microemboli, and patients had twice as much white matter hyperintensity as controls. CONCLUSIONS These data show that physical measures of plaque instability are possible through interpretation of ultrasound strain data during pulsation, which may be more clinically relevant than solely measuring degree of stenosis. The data also highlight the importance of understanding that the definition of symptoms should not be limited to motor, speech, and vision function but underscore the role of vascular cognitive decline in the pathophysiology of carotid atherosclerotic disease. Clinical trial registration no.: NCT02476396 (clinicaltrials.gov).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.