ArticleCell reports2017
Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 43 citations in OpenAlex.
- Multimodal characterization of transcriptionally defined ventral tegmental area dopamine neurons.bioRxiv : the preprint server for biology · 2026Article
- Context-tuned strategies for marker selection precision in neuronal studies.Frontiers in neuroscience · 2026Review
- Evidence for age-related vulnerability in dopamine-glutamate projections to the lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- Untangling dopamine and glutamate in the ventral tegmental area.bioRxiv : the preprint server for biology · 2025Article
- The learning primacy hypothesis of dopamine: reconsidering dopamine's dual functions.Frontiers in cellular neuroscience · 2025Review
- Dopamine-Glutamate and Dopamine-GABA Co-release.Advances in neurobiology · 2025Review
- Constraints on the subsecond modulation of striatal dynamics by physiological dopamine signaling.Nature neuroscience · 2024Article
- Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release.Neuron · 2024Article
- Simultaneous detection of neurotransmitters and CuRSC advances · 2023Article
- Clock gene-dependent glutamate dynamics in the bean bug brain regulate photoperiodic reproduction.PLoS biology · 2022Article
- Illuminating subcortical GABAergic and glutamatergic circuits for reward and aversion.Neuropharmacology · 2021Review
- Dopamine, Updated: Reward Prediction Error and Beyond.Current opinion in neurobiology · 2021Review
- Glutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior.Neurochemistry international · 2021Review
- Deletion of VGLUT2 in midbrain dopamine neurons attenuates dopamine and glutamate responses to methamphetamine in mice.Pharmacology, biochemistry, and behavior · 2021Article
- Genetic Probe for Visualizing Glutamatergic Synapses and Vesicles by 3D Electron Microscopy.ACS chemical neuroscience · 2021Article
- Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior.Frontiers in neural circuits · 2021Article
- Dopamine Neurons That Cotransmit Glutamate, From Synapses to Circuits to Behavior.Frontiers in neural circuits · 2021Review
- VTA Glutamate Neuron Activity Drives Positive Reinforcement Absent Dopamine Co-release.Neuron · 2020Article
- Altered Corticolimbic Control of the Nucleus Accumbens by Long-term ΔBiological psychiatry · 2020Article
- Dopamine transients do not act as model-free prediction errors during associative learning.Nature communications · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Dopamine neurons in the ventral tegmental area (VTA) were previously found to express vesicular glutamate transporter 2 (VGLUT2) and to co-transmit glutamate in the ventral striatum (VStr). This capacity may play an important role in reinforcement learning. Although it is known that activation of the VTA-VStr dopamine system readily reinforces behavior, little is known about the role of glutamate co-transmission in such reinforcement. By combining electrode recording and optogenetics, we found that stimulation of VTA dopamine neurons in vivo evoked fast excitatory responses in many VStr neurons of adult mice. Whereas conditional knockout of the gene encoding VGLUT2 in dopamine neurons largely eliminated fast excitatory responses, it had little effect on the acquisition of conditioned responses reinforced by dopamine neuron activation. Therefore, glutamate co-transmission appears dispensable for acquisition of conditioned responding reinforced by DA neuron activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.