ArticleBiophysical journal2017
Moving in the Right Direction: Protein Vibrations Steering Function.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Terahertz calorimetry spotlights the role of water in biological processes.Nature reviews. Chemistry · 2025Review
- Vibrational Analysis of Hydration-Layer Water around Ubiquitin, Unpeeled Layer by Layer: Molecular-Dynamics Perceptions.International journal of molecular sciences · 2022Article
- Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering.Structure (London, England : 1993) · 2022Article
- Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code.International journal of molecular sciences · 2022Review
- Joint neutron/molecular dynamics vibrational spectroscopy reveals softening of HIV-1 protease upon binding of a tight inhibitor.Physical chemistry chemical physics : PCCP · 2022Article
- Low-frequency vibrational modes in G-quadruplexes reveal the mechanical properties of nucleic acids.Physical chemistry chemical physics : PCCP · 2021Article
- Machine Learning of Allosteric Effects: The Analysis of Ligand-Induced Dynamics to Predict Functional Effects in TRAP1.The journal of physical chemistry. B · 2021Article
- Terahertz Spectroscopy Tracks Proteolysis by a Joint Analysis of Absorptance and Debye Model.Biophysical journal · 2020Article
- Substrate Binding Stiffens Aspartate Aminotransferase by Altering the Enzyme Picosecond Vibrational Dynamics.ACS omega · 2020Article
- DROIDS 3.0-Detecting Genetic and Drug Class Variant Impact on Conserved Protein Binding Dynamics.Biophysical journal · 2020Article
- Clustering of atomic displacement parameters in bovine trypsin reveals a distributed lattice of atoms with shared chemical properties.Scientific reports · 2019Article
- Near-field THz micropolarimetry.Optics express · 2019Article
- Stationary Sample Anisotropic THz Spectroscopy using Discretely Tunable THz Sources.International Conference on Infrared, Millimeter, and Terahertz Waves : [proceedings]. International Conference on Infrared, Millimeter, and Terahertz Waves · 2019Article
- Strong coupling of collective intermolecular vibrations in organic materials at terahertz frequencies.Nature communications · 2019Article
- Tunable compact narrow band THz sources for frequency domain THz anisotropic spectroscopy.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Protein and RNA dynamical fingerprinting.Nature communications · 2019Article
- THz Anisotropy Identification using Tunable Compact Narrow Band THz Sources.International Conference on Infrared, Millimeter, and Terahertz Waves : [proceedings]. International Conference on Infrared, Millimeter, and Terahertz Waves · 2018Article
- Role of Terahertz (THz) Fluctuations in the Allosteric Properties of the PDZ Domains.The journal of physical chemistry. B · 2017Article
- Pickin' Up Good Vibrations.Biophysical journal · 2017Article
- Molecular Dynamics Simulations of Macromolecular Crystals.Wiley interdisciplinary reviews. Computational molecular scienceArticle
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nearly all protein functions require structural change, such as enzymes clamping onto substrates, and ion channels opening and closing. These motions are a target for possible new therapies; however, the control mechanisms are under debate. Calculations have indicated protein vibrations enable structural change. However, previous measurements found these vibrations only weakly depend on the functional state. By using the novel technique of anisotropic terahertz microscopy, we find that there is a dramatic change to the vibrational directionality with inhibitor binding to lysozyme, whereas the vibrational energy distribution, as measured by neutron inelastic scattering, is only slightly altered. The anisotropic terahertz measurements provide unique access to the directionality of the intramolecular vibrations, and immediately resolve the inconsistency between calculations and previous measurements, which were only sensitive to the energy distribution. The biological importance of the vibrational directions versus the energy distribution is revealed by our calculations comparing wild-type lysozyme with a higher catalytic rate double deletion mutant. The vibrational energy distribution is identical, but the more efficient mutant shows an obvious reorientation of motions. These results show that it is essential to characterize the directionality of motion to understand and control protein dynamics to optimize or inhibit function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.