ArticleBiophysical journal2017
Signal Destruction Tunes the Zone of Activation in Spatially Distributed Signaling Networks.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Phage-mediated intercellular CRISPRi for biocomputation in bacterial consortia.Nucleic acids research · 2025Article
- Revealing gene regulation-based neural network computing in bacteria.Biophysical reports · 2023Article
- Intertemporal trade-off between population growth rate and carrying capacity during public good production.iScience · 2022Article
- A tunable population timer in multicellular consortia.iScience · 2021Article
- Short-range quorum sensing controls horizontal gene transfer at micron scale in bacterial communities.Nature communications · 2021Article
- Spiral Wave Propagation in Communities with Spatially Correlated Heterogeneity.Biophysical journal · 2020Article
- Statistics of correlated percolation in a bacterial community.PLoS computational biology · 2019Article
- A neural network model predicts community-level signaling states in a diverse microbial community.PLoS computational biology · 2019Article
- Quantifying the strength of quorum sensing crosstalk within microbial communities.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverse microbial communities coordinate group behaviors through signal exchange, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria. Cellular communication is prone to interference by neighboring microbes. One mechanism of interference is signal destruction through the production of an enzyme that cleaves the signaling molecule. Here we examine the ability of one such interference enzyme, AiiA, to modulate signal propagation in a spatially distributed system of bacteria. We have developed an experimental assay to measure signal transduction and implement a theoretical model of signaling dynamics to predict how the system responds to interference. We show that titration of an interfering strain into a signaling network tunes the spatial range of activation over the centimeter length scale, quantifying the robustness of the signaling network to signal destruction and demonstrating the ability to program systems-level responses of spatially heterogeneous cellular networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.