ArticleStem cells translational medicine2017
Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.
Article in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04057833 (A Phase 1 Open-Label, Single-Center Investigator Initiated Trial), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 1 Open-Label, Single-Center Investigator Initiated Trial (IIT) of E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- The challenges and optimization of cell-based therapy for cardiovascular disease.Journal of translational internal medicine · 2021Review
- Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells.Molecular therapy. Methods & clinical development · 2021Article
- Advances in preclinical hematopoietic stem cell models and possible implications for improving therapeutic transplantation.Stem cells translational medicine · 2021Review
- PEDF promotes the repair of bone marrow endothelial cell injury and accelerates hematopoietic reconstruction after bone marrow transplantation.Journal of biomedical science · 2020Article
- Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells.Stem cell research & therapy · 2020Article
- Induction of developmental hematopoiesis mediated by transcription factors and the hematopoietic microenvironment.Annals of the New York Academy of Sciences · 2020Review
- Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance.International journal of molecular sciences · 2020Review
- Blood making: learning what to put into the dish.F1000Research · 2020Review
- Endothelial cells produce angiocrine factors to regulate bone and cartilage via versatile mechanisms.Theranostics · 2020Review
- Molecular determinants of nephron vascular specialization in the kidney.Nature communications · 2019Article
- Evaluating Interaction of Cord Blood Hematopoietic Stem/Progenitor Cells with Functionally Integrated Three-Dimensional Microenvironments.Stem cells translational medicine · 2018Article
- Stromalized microreactor supports murine hematopoietic progenitor enrichment.Biomedical microdevices · 2018Article
- Development of Human Mast Cells from Hematopoietic Stem Cells within a 3D Collagen Matrix: Effect of Stem Cell Media on Mast Cell Generation.Stem cells international · 2018Article
- Tissue-specific endothelial cells: a promising approach for augmentation of soft tissue repair in orthopedics.Annals of the New York Academy of Sciences · 2017Review
- Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Regulation of the hematopoietic stem cell lifecycle by the endothelial niche.Current opinion in hematology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Successful expansion of bone marrow (BM) hematopoietic stem and progenitor cells (HSPCs) would benefit many HSPC transplantation and gene therapy/editing applications. However, current expansion technologies have been limited by a loss of multipotency and self-renewal properties ex vivo. We hypothesized that an ex vivo vascular niche would provide prohematopoietic signals to expand HSPCs while maintaining multipotency and self-renewal. To test this hypothesis, BM autologous CD34
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.