Evidence map›Paper›PMID 28296941›Full record

ArticlePloS one2017

The association between methylphenidate treatment and the risk for fracture among young ADHD patients: A nationwide population-based study in Taiwan.

Vincent Chin-Hung Chen, Yao-Hsu Yang, Yin-To Liao, Ting-Yu Kuo, Hsin-Yi Liang, Kuo-You Huang, Yin-Cheng Huang, Yena Lee, Roger S McIntyre, Tzu-Chin Lin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Vincent Chin-Hung ChenChang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Chiayi County, Taiwan.
Yao-Hsu YangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chia-Yi, Taiwan.
Yin-To LiaoDepartment of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan.
Ting-Yu KuoCenter of Excellence for Chang Gung Research Datalink, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Hsin-Yi LiangDepartment of Medicine, School of Medicine, Chang Gung University, Tao-Yuan, Taiwan.
Kuo-You HuangDepartment of Speech, Language Pathology and Audiology, Chung Shan Medical University, Taichung, Taiwan.
Yin-Cheng HuangDepartment of Neurosurgery, Chang Gung Memorial Hospital, Chiayi.
Yena LeeMood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Canada.
Roger S McIntyreMood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, Canada.
Tzu-Chin LinSchool of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0003-3450-8200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attention-deficit hyperactivity disorder (ADHD) is associated with higher risk for fracture. Whether the medical treatment for ADHD would mitigate the risk remains unclear. In this study, we sought to investigate the effect of methylphenidate treatment on risk for fracture, as well the moderational role of treatment duration on the risk of fracture, in a large national sample. Cases less than 18 years old were identified from Taiwan's National Health Insurance Research Database with a new primary diagnosis of ADHD (ICD-9:314) between 1996 and 2013. A total of 6201 cases with ADHD were included as the study cohort. The cases were divided into 3 groups according to the duration of methylphenidate treatment (0, 1-180, and more than 180 days). All groups were followed until the end of 2013 for first diagnoses of fracture (ICD-9 codes 800 to 829). Cox proportional hazards models were applied. Compared to the group without methylphenidate treatment, the risk for fracture was lower among the group treated for more than 180 days. The adjusted hazard ratio was 0.77 (95% Confidence interval: 0.63-0.94). The groups treated for 180 days or fewer had no significant difference in the risk for fracture. In conclusion, methylphenidate treatment was associated with lower risk for fracture among ADHD patients. The association was evident only in the cohort treated for more than 180 days.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityChildChild, PreschoolFemaleFractures, BoneHumansInfantInfant, NewbornMaleMethylphenidatePopulation SurveillanceRetrospective StudiesTaiwanMethylphenidate

Identifiers

PMID28296941
PMCPMC5351966

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.