ArticlePLoS neglected tropical diseases2017
Detection and characterization of Brucella spp. in bovine milk in small-scale urban and peri-urban farming in Tajikistan.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Beyond Serology: A Meta-Analysis of Advancements in Molecular Detection of Brucella spp. in Seronegative Animals and Biological Samples.Veterinary medicine and science · 2025Pooled it
- Seroprevalence of Brucellosis in Buffalo Worldwide and Associated Risk Factors: A Systematic Review and Meta-Analysis.Frontiers in veterinary science · 2021Pooled it
- Article
- Detection of Brucella spp. from milk by quantitative PCR as a monitoring method for brucellosis in cattle in Mongolia.BMC veterinary research · 2025Article
- Hybrid Whole Genomes ofMicroorganisms · 2025Article
- Can qPCR on pooled sheep milk detect brucellosis as part of herd brucellosis control and eradication programs?BMC veterinary research · 2025Article
- Long ignored but making a comeback: a worldwide epidemiological evolution of human brucellosis.Emerging microbes & infections · 2024Review
- Review of the Current Status on Ruminant Abortigenic Pathogen Surveillance in Africa and Asia.Veterinary sciences · 2024Review
- An Epidemiological Study of Brucellosis in Different Animal Species from the Al-Qassim Region, Saudi Arabia.Vaccines · 2023Article
- Brucellae as resilient intracellular pathogens: epidemiology, host-pathogen interaction, recent genomics and proteomics approaches, and future perspectives.Frontiers in veterinary science · 2023Review
- First record of the human infection of Brucella melitensis in Kyrgyzstan: evidence from whole-genome sequencing-based analysis.Infectious diseases of poverty · 2022Article
- Article
- The Importance of Complementary PCR Analysis in Addition to Serological Testing for the Detection of Transmission Sources ofVeterinary sciences · 2022Article
- Article
- Importance of brucellosis control programs of livestock on the improvement of one health.The veterinary quarterly · 2021Review
- Bovine brucellosis - a comprehensive review.The veterinary quarterly · 2021Review
- Isolation of Brucella abortus and Brucella melitensis from Seronegative Cows is a Serious Impediment in Brucellosis Control.Veterinary sciences · 2018Article
- Detection ofVeterinary world · 2018Article
- Evolution of bovine brucellosis in Colombia over a 7-year period (2006-2012).Tropical animal health and production · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucellosis is one of the most common zoonoses globally, and Central Asia remains a Brucella hotspot. The World Health Organization classifies brucellosis as a neglected zoonotic disease that is rarely in the spotlight for research and mainly affects poor, marginalized people. Urban and peri-urban farming is a common practice in many low-income countries, and it increases the incomes of families that are often restrained by limited economic resources. However, there is a concern that the growing number of people and livestock living close together in these areas will increase the transmission of zoonotic pathogens such as Brucella. This study investigates the presence of Brucella DNA in bovine milk in the urban and peri-urban area of Dushanbe, Tajikistan. Brucella DNA was detected in 10.3% of 564 cow milk samples by IS711-based real-time PCR. This finding is concerning because consumption of unpasteurized dairy products is common in the region. Furthermore, Brucella DNA was detected in the milk of all seropositive cows, but 8.3% of the seronegative cows also showed the presence of Brucella DNA. In addition, sequence analysis of the rpoB gene suggests that one cow was infected with B. abortus and another cow was most likely infected with B. melitensis. The discrepancies between the serology and real-time PCR results highlight the need to further investigate whether there is a need for implementing complementary diagnostic strategies to detect false serological negative individuals in Brucella surveillance, control, and eradication programmes. Furthermore, vaccination of cattle with S19 in addition to vaccination of small ruminants with Rev 1 might be needed in order to control Brucella infections in the livestock population but further research focusing on the isolation of Brucella is required to obtain a comprehensive understanding of the Brucella spp. circulating among the livestock in this region.
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Registered trials
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