Evidence map›Paper›PMID 28296804›Full record

ArticleAIDS (London, England)2017

Statistical models for incorporating data from routine HIV testing of pregnant women at antenatal clinics into HIV/AIDS epidemic estimates.

Ben Sheng, Kimberly Marsh, Aleksandra B Slavkovic, Simon Gregson, Jeffrey W Eaton, Le Bao

Abstract read
In one paragraph

Article in AIDS (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ben ShengaDepartment of Statistics, Pennsylvania State University, University Park, Pennsylvania, USA bStrategic Information and Monitoring Division, UNAIDS, Geneva, Switzerland cDepartment of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.
Kimberly Marsh
Aleksandra B Slavkovic
Simon Gregson
Jeffrey W Eaton
Le Bao

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Statistical Models for Estimating and Projecting HIV/AIDS EpidemicsR01AI136664 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI BAO, LE · 2017 to 2021
$3.6M
Estimation and Projection of HIV/AIDS EpidemicsR56AI120812 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI BAO, LE · 2016 to 2016
$383k
Quantifying Spatial Representativeness and Uncertainty in Antenatal Care Sentinel Surveillance for HIV in Sub-Saharan Africa.R03AI125001 · NIAID · IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · PI EATON, JEFFREY WILLIAM · 2017 to 2018
$105k
NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1 TR002014NIAID NIH HHS R01 AI136664NIAID NIH HHS R03 AI125001NIAID NIH HHS R56 AI120812
6 · The paper itself

Abstract

objectiveHIV prevalence data collected from routine HIV testing of pregnant women at antenatal clinics (ANC-RT) are potentially available from all facilities that offer testing services to pregnant women and can be used to improve estimates of national and subnational HIV prevalence trends. We develop methods to incorporate these new data source into the Joint United Nations Programme on AIDS Estimation and Projection Package in Spectrum 2017.

methodsWe develop a new statistical model for incorporating ANC-RT HIV prevalence data, aggregated either to the health facility level (site-level) or regionally (census-level), to estimate HIV prevalence alongside existing sources of HIV prevalence data from ANC unlinked anonymous testing (ANC-UAT) and household-based national population surveys. Synthetic data are generated to understand how the availability of ANC-RT data affects the accuracy of various parameter estimates.

resultsWe estimate HIV prevalence and additional parameters using both ANC-RT and other existing data. Fitting HIV prevalence using synthetic data generally gives precise estimates of the underlying trend and other parameters. More years of ANC-RT data should improve prevalence estimates. More ANC-RT sites and continuation with existing ANC-UAT sites may improve the estimate of calibration between ANC-UAT and ANC-RT sites.

conclusionWe have proposed methods to incorporate ANC-RT data into Spectrum to obtain more precise estimates of prevalence and other measures of the epidemic. Many assumptions about the accuracy, consistency, and representativeness of ANC-RT prevalence underlie the use of these data for monitoring HIV epidemic trends and should be tested as more data become available from national ANC-RT programs.

Indexed as

Models, StatisticalAdolescentAdultEpidemicsFemaleHIV InfectionsHumansMiddle AgedPregnancyPregnancy Complications, InfectiousPrenatal CarePrevalenceYoung Adult

Identifiers

PMID28296804
PMCPMC5356494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.