Evidence map›Paper›PMID 28296542›Full record

ArticleAutophagy2017

The autophagy machinery restrains iNKT cell activation through CD1D1 internalization.

Christian W Keller, Monica Loi, Svenja Ewert, Isaak Quast, Romina Theiler, Monique Gannagé, Christian Münz, Gennaro De Libero, Stefan Freigang, Jan D Lünemann

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Autophagy pathways in autoimmune diseases.Journal of autoimmunity · 2023
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. The autophagic network and cancer.Nature cell biology · 2018
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Hormesis and Defense of Infectious Disease.International journal of molecular sciences · 2017
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Christian W Kellera Institute of Experimental Immunology, Laboratory of Neuroinflammation, University of Zurich , Zurich , Switzerland.
Monica Loib Institute of Experimental Immunology, Laboratory of Viral Immunobiology, University of Zurich , Zurich , Switzerland.
Svenja Ewertc Institute of Pathology, Laboratory of Immunopathology, University of Bern , Bern , Switzerland.
Isaak Quasta Institute of Experimental Immunology, Laboratory of Neuroinflammation, University of Zurich , Zurich , Switzerland.
Romina Theilerc Institute of Pathology, Laboratory of Immunopathology, University of Bern , Bern , Switzerland.
Monique Gannagée Department of Pathology and Immunology , School of Medicine - CMU, University of Geneva , Geneva , Switzerland.
Christian Münzb Institute of Experimental Immunology, Laboratory of Viral Immunobiology, University of Zurich , Zurich , Switzerland.
Gennaro De Liberog Singapore Immunology Network , Agency for Science, Technology and Research (A*STAR) , Singapore.
Stefan Freigangc Institute of Pathology, Laboratory of Immunopathology, University of Bern , Bern , Switzerland.
Jan D Lünemanna Institute of Experimental Immunology, Laboratory of Neuroinflammation, University of Zurich , Zurich , Switzerland.
University of Zurich · CHUniversity of Bern · CHMonash University · AUSingapore Immunology Network · SGUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invariant natural killer T (iNKT) cells are innate T cells with powerful immune regulatory functions that recognize glycolipid antigens presented by the CD1D protein. While iNKT cell-activating glycolipids are currently being explored for their efficacy to improve immunotherapy against infectious diseases and cancer, little is known about the mechanisms that control CD1D antigen presentation and iNKT cell activation in vivo. CD1D molecules survey endocytic pathways to bind lipid antigens in MHC class II-containing compartments (MIICs) before recycling to the plasma membrane. Autophagosomes intersect with MIICs and autophagy-related proteins are known to support antigen loading for increased CD4

Indexed as

AutophagyEndocytosisAdaptor Protein Complex 2AnimalsAntigensAntigens, CD1dAutophagy-Related Protein 5Bacterial InfectionsCell MembraneCells, CulturedDendritic CellsEndosomesGlycolipidsImmunizationLipidsMice, Inbred C57BLAdaptor Protein Complex 2AntigensAntigens, CD1dAutophagy-Related Protein 5GlycolipidsLipidsantigen presentationautophagyCD1D1dendritic cellsglycolipidinnate-like lymphocytesinternalizationNKT cellT cell

Identifiers

PMID28296542
PMCPMC5486365
OpenAlexW2604460554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.