ArticleNano letters2017
AC Electroosmosis-Enhanced Nanoplasmofluidic Detection of Ultralow-Concentration Cytokine.
Article in Nano letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 71 citations in OpenAlex.
- Lab-on-a-chip device with an integrated surface acoustic wave micromixer for enhanced porous silicon biosensor performance.RSC advances · 2026Article
- Ultrasound-enabled refreshable electrochemical sensors for cardiac biomarker monitoring.Biosensors & bioelectronics · 2026Article
- A Promising Point-of-Care Testing Strategy: Ultrasmooth Gold Nanogroove Arrays Biosensor Combined with Initial Rate Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Rapid HER2-positive cell detection via high-voltage electroosmotic flow-driven microfluidic SPRi.Mikrochimica acta · 2025Article
- Cancer-on-a-chip for precision cancer medicine.Lab on a chip · 2025Review
- Nanoplasmonic biosensors for environmental sustainability and human health.Chemical Society reviews · 2024Review
- Asymmetric Rectified Electric Fields for Symmetric Electrolytes.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Constrained Volume Micro- and Nanoparticle Collection Methods in Microfluidic Systems.Micromachines · 2024Review
- Article
- The perspectives of broadband metasurfaces and photo-electric tweezer applications.Nanophotonics (Berlin, Germany) · 2022Review
- AC-Electroosmosis-Assisted Surface Plasmon Resonance Sensing for Enhancing Protein Signals with a Simple Kretschmann Configuration.Sensors (Basel, Switzerland) · 2022Article
- Sensing Inflammation Biomarkers with Electrolyte-Gated Organic Electronic Transistors.Advanced healthcare materials · 2021Review
- Machine learning-based cytokine microarray digital immunoassay analysis.Biosensors & bioelectronics · 2021Article
- Article
- A digital protein microarray for COVID-19 cytokine storm monitoring.Lab on a chip · 2021Article
- Application of Microfluidics in Immunoassay: Recent Advancements.Journal of healthcare engineering · 2021Review
- Point-of-care-ready nanoscale ISFET arrays for sub-picomolar detection of cytokines in cell cultures.Analytical and bioanalytical chemistry · 2020Article
- Novel Nanoplasmonic-Structure-Based Integrated Microfluidic Biosensors for Label-Free in Situ Immune Functional Analysis: A review of recent progress.IEEE nanotechnology magazine · 2020Article
- Phase-controlled field-effect micromixing using AC electroosmosis.Microsystems & nanoengineering · 2020Article
- Biomarkers in pediatric acute respiratory distress syndrome.Annals of translational medicine · 2019Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Label-free, nanoparticle-based plasmonic optical biosensing, combined with device miniaturization and microarray integration, has emerged as a promising approach for rapid, multiplexed biomolecular analysis. However, limited sensitivity prevents the wide use of such integrated label-free nanoplasmonic biosensors in clinical and life science applications where low-abundance biomolecule detection is needed. Here, we present a nanoplasmofluidic device integrated with microelectrodes for rapid, label-free analysis of a low-abundance cell signaling protein, detected by AC electroosmosis-enhanced localized surface plasmon resonance (ACE-LSPR) biofunctional nanoparticle imaging. The ACE-LSPR device is constructed using both bottom-up and top-down sensor fabrication methods, allowing the seamless integration of antibody-conjugated gold nanorod (AuNR) biosensor arrays with microelectrodes on the same microfluidic platform. Applying an AC voltage to microelectrodes while scanning the scattering light intensity variation of the AuNR biosensors results in significantly enhanced biosensing performance. The AC electroosmosis (ACEO) based enhancement of the biosensor performance enables rapid (5-15 min) quantification of IL-1β, a pro-inflammatory cytokine biomarker, with a sensitivity down to 158.5 fg/mL (9.1 fM) for spiked samples in PBS and 1 pg/mL (58 fM) for diluted human serum. Together with the optimized detection sensitivity and speed, our study presents the first critical step toward the application of nanoplasmonic biosensing technology to immune status monitoring guided by low-abundance cytokine measurement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.