ArticleObesity (Silver Spring, Md.)2017
Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index.
Article in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.International journal of obesity (2005) · 2021Pooled it
- Harnessing data science to control non-communicable diseases in Africa: a systematic review and gap analysis.Communications medicine · 2026Article
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Observational
- Genome-wide association study of neck circumference identifies sex-specific loci independent of generalized adiposity.International journal of obesity (2005) · 2021Article
- Non-communicable diseases pandemic and precision medicine: Is Africa ready?EBioMedicine · 2021Review
- Genetic underpinnings of regional adiposity distribution in African Americans: Assessments from the Jackson Heart Study.PloS one · 2021Article
- Genetic and Genomic Advances in Developmental Models: Applications for Nutrition Research.Advances in nutrition (Bethesda, Md.) · 2020Review
- Interaction between Metabolic Genetic Risk Score and Dietary Fatty Acid Intake on Central Obesity in a Ghanaian Population.Nutrients · 2020Article
- A Call to Action-The Need to Address Obesity in the Black Community.Journal of the National Medical Association · 2020Article
- Evaluating the promise of inclusion of African ancestry populations in genomics.NPJ genomic medicine · 2020Review
- Genetics of Obesity in East Asians.Frontiers in genetics · 2020Review
- Genetic Basis of Obesity and Type 2 Diabetes in Africans: Impact on Precision Medicine.Current diabetes reports · 2019Review
- Maternal BMI-Increasing Genetic Risk Score and Fetal Weights among Diverse US Ethnic Groups.Obesity (Silver Spring, Md.) · 2019Article
- Prospects of genetic testing for steroid-resistant nephrotic syndrome in Nigerian children: a narrative review of challenges and opportunities.International journal of nephrology and renovascular disease · 2019Review
- Insulin Resistance and Metabolic Syndrome: Clinical and Laboratory Associations in African Americans Without Diabetes in the Hemochromatosis and Iron Overload Screening Study.Metabolic syndrome and related disorders · 2018Article
- Racial Disparities in Obesity Treatment.Current obesity reports · 2018Review
- Medical genetics and genomic medicine in Nigeria.Molecular genetics & genomic medicine · 2018Article
- Cardiovascular effects of metabolic syndrome after transplantation: convergence of obesity and transplant-related factors.Clinical kidney journal · 2018Article
- Social and behavioral science priorities for genomic translation.Translational behavioral medicine · 2018Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 3 countries.
Funding
Abstract
objectiveThe prevalence of obesity varies between ethnic groups. No genome-wide association study (GWAS) for body mass index (BMI) has been conducted in continental Africans.
methodsWe performed a GWAS for BMI in 1,570 West Africans (WA). Replication was conducted in independent samples of WA (n = 1,411) and African Americans (AA) (n = 9,020).
resultsWe identified a novel genome-wide significant African-specific locus for BMI (SEMA4D, rs80068415; minor allele frequency = 0.008, P = 2.10 × 10
conclusionsA novel variant in SEMA4D was significantly associated with BMI. Carriers of the C allele were 4.6 BMI units heavier than carriers of the T allele (P = 0.0007). This variant is monomorphic in Europeans and Asians, highlighting the importance of studying diverse populations. While there is evidence for the involvement of SEMA4D in inflammatory processes, this study is the first to implicate SEMA4D in obesity pathophysiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.