Evidence map›Paper›PMID 28296255›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017

Regulatory B Cell-Dependent Islet Transplant Tolerance Is Also Natural Killer Cell Dependent.

C Schuetz, K M Lee, R Scott, L Kojima, L Washburn, L Liu, W-H Liu, H Tector, J Lei, H Yeh and 2 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Adjuvant conditioning induces an immunosuppressive milieu that delays alloislet rejection through the expansion of myeloid-derived suppressor cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Properties of regulatory B cells regulating B cell targets.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  9. Review
  10. Regulatory B cells and transplantation: almost prime time?Current opinion in organ transplantation · 2018
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

C SchuetzDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
K M LeeDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
R ScottDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
L KojimaDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
L WashburnDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
L LiuDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
W-H LiuDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
H TectorDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
J LeiDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
H YehDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
J I KimDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
J F MarkmannDivision of Transplantation, Department of Surgery, Massachusetts General Hospital, Boston, MA.
Massachusetts General Hospital · US

Funding

Mechanisms of B Cell-Dependent Transplantation ToleranceR01AI057851 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI JAMES FRANCIS MARKMANN · 2006 to 2026
$8.9M
Role of B Cells in Transplant ToleranceK08DK094965 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI YEH, HEIDI · 2012 to 2016
$794k
NIAID NIH HHS R01 AI057851NIDDK NIH HHS K08 DK094965
6 · The paper itself

Abstract

Immunologic tolerance to solid organ and islet cell grafts has been achieved in various rodent models by using antibodies directed at CD45RB and Tim-1. We have shown that this form of tolerance depends on regulatory B cells (Bregs). To elucidate further the mechanism by which Bregs induce tolerance, we investigated the requirement of natural killer (NK) and NKT cells in this model. To do so, hyperglycemic B6, μMT, Beige, or CD1d

Indexed as

AnimalsAntibodies, MonoclonalB-Lymphocytes, RegulatoryFemaleIslets of Langerhans TransplantationKiller Cells, NaturalMaleMiceMice, Inbred BALB CMice, Inbred C57BLNatural Killer T-CellsTransplantation ToleranceAntibodies, Monoclonalbasic (laboratory) research/scienceB cell biologyimmunobiologyislet transplantationnatural killer (NK) cells/NK receptorstolerance

Identifiers

PMID28296255
PMCPMC5444975
OpenAlexW2594907191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.