Evidence map›Paper›PMID 28296182›Full record

ReviewStem cells translational medicine2017

Endothelial Progenitors: A Consensus Statement on Nomenclature.

Reinhold J Medina, Chad L Barber, Florence Sabatier, Francoise Dignat-George, Juan M Melero-Martin, Kiarash Khosrotehrani, Osamu Ohneda, Anna M Randi, Jerry K Y Chan, Teruhide Yamaguchi and 3 more

Abstract readReviewConsensus Statement
In one paragraph

Review in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 272 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
272citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

272 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. The role of extracellular vesicles in kidney disease progression.Kidney research and clinical practice · 2026
    Article

212 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Reinhold J MedinaCentre for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
Chad L BarberDepartment of Biology, California Lutheran University, Thousand Oaks, California, USA.
Florence SabatierVascular Research Centre Marseille, INSERM, Aix Marseille Université, Marseille, France.
Francoise Dignat-GeorgeVascular Research Centre Marseille, INSERM, Aix Marseille Université, Marseille, France.
Juan M Melero-MartinDepartment of Cardiac Surgery, Boston Children's Hospital, Massachusetts, USA.
Kiarash KhosrotehraniUniversity of Queensland Centre for Clinical Research, Herston, Queensland, Australia.
Osamu OhnedaLab of Regenerative Medicine and Stem Cell Biology, University of Tsukuba, Tsukuba, Japan.
Anna M RandiNational Heart and Lung Institute (NHLI) Vascular Sciences, Imperial College London, London, United Kingdom.
Jerry K Y ChanDepartment of Reproductive Medicine, KK Women's and Children's Hospital, Singapore.
Teruhide YamaguchiUniversity of Kanazawa Technical Institute, Ishikawa, Japan.
Victor W M Van HinsberghDepartment of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.
Mervin C YoderDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alan W StittCentre for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.

Funding

Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
Vascular networks genetically engineered for protein drug deliveryR01HL128452 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI MELERO-MARTIN, JUAN M, WANG, BO · 2015 to 2024
$4.8M
Vascular niche bioengineering for human bone regenerationR01AR069038 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI MELERO-MARTIN, JUAN M · 2016 to 2020
$1.9M
Host neutrophils as direct mediators of tissue graft revascularizationR21AI123883 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI MELERO-MARTIN, JUAN M · 2016 to 2017
$487k
Medical Research Council G0600053Medical Research Council MC_PC_16083NHLBI NIH HHS R01 HL128452NIAID NIH HHS R21 AI123883NIAMS NIH HHS R01 AR069038NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct cell subtypes continually grouped under the term "EPC." It would be highly advantageous to agree on standards to confirm an endothelial progenitor phenotype and this should include detailed immunophenotyping, potency assays, and clear separation from hematopoietic angiogenic cells which are not endothelial progenitors. In this review, we seek to discourage the indiscriminate use of "EPCs," and instead propose precise terminology based on defining cellular phenotype and function. Endothelial colony forming cells and myeloid angiogenic cells are examples of two distinct and well-defined cell types that have been considered EPCs because they both promote vascular repair, albeit by completely different mechanisms of action. It is acknowledged that scientific nomenclature should be a dynamic process driven by technological and conceptual advances; ergo the ongoing "EPC" nomenclature ought not to be permanent and should become more precise in the light of strong scientific evidence. This is especially important as these cells become recognized for their role in vascular repair in health and disease and, in some cases, progress toward use in cell therapy. Stem Cells Translational Medicine 2017;6:1316-1320.

Indexed as

AnimalsCell- and Tissue-Based TherapyEndothelial Progenitor CellsHumansNeovascularization, PhysiologicTerminology as TopicAngiogenesisCellular therapyEndothelial cellProgenitor cells

Identifiers

PMID28296182
PMCPMC5442722

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.