Evidence map›Paper›PMID 28296029›Full record

ArticleJournal of cellular and molecular medicine2017

CD38 promotes angiotensin II-induced cardiac hypertrophy.

Xiao-Hui Guan, Xuan Hong, Ning Zhao, Xiao-Hong Liu, Yun-Fei Xiao, Ting-Tao Chen, Li-Bin Deng, Xiao-Lei Wang, Jian-Bin Wang, Guang-Ju Ji and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 90 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. CD38 connects the heart and brain.Translational psychiatry · 2025
    Review
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  7. Emerging interactions between mitochondria and NADTrends in endocrinology and metabolism: TEM · 2025
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  10. NAD metabolism and heart failure: Mechanisms and therapeutic potentials.Journal of molecular and cellular cardiology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Xiao-Hui GuanInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Xuan HongInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Ning ZhaoInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Xiao-Hong LiuInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Yun-Fei XiaoInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Ting-Tao ChenInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Li-Bin DengInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Xiao-Lei WangInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Jian-Bin WangInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Guang-Ju JiNational Laboratory of Biomacromolecules, Institute of Biophysics Chinese Academy of Sciences, Beijing, China.
Mingui FuDepartment of Basic Medical Science, Shock/Trauma Research Center, School of Medicine, University of Missouri Kansas City, Kansas City, MO, USA.
Ke-Yu DengInstitute of Translational Medicine, Nanchang University, Nanchang, China.
Hong-Bo XinInstitute of Translational Medicine, Nanchang University, Nanchang, China.ORCID 0000-0002-4257-207X
Nanchang University · CNChinese Academy of Sciences · CNUniversity of Missouri–Kansas City · US

Funding

Ribonuclease-mediated control of sepsis-induced systemic inflammationR15AI138116 · NIAID · UNIVERSITY OF MISSOURI KANSAS CITY · PI FU, MINGUI · 2019 to 2019
$465k
Post-transcriptional Regulation of Cytokine ProductionR21AI103618 · NIAID · UNIVERSITY OF MISSOURI KANSAS CITY · PI FU, MINGUI · 2014 to 2015
$415k
NIAID NIH HHS R15 AI138116NIAID NIH HHS R21 AI103618
6 · The paper itself

Abstract

Cardiac hypertrophy is an early hallmark during the clinical course of heart failure and regulated by various signalling pathways. Recently, we observed that mouse embryonic fibroblasts from CD38 knockout mice were significantly resistant to oxidative stress such as H

Indexed as

ADP-ribosyl Cyclase 1Angiotensin IIAnimalsAtrial Natriuretic FactorCalciumCardiomegalyCell LineForkhead Box Protein O3Gene Expression RegulationMembrane GlycoproteinsMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MyocardiumMyocytes, CardiacADP-ribosyl Cyclase 1Angiotensin IIAtrial Natriuretic FactorCalciumCd38 protein, mouseForkhead Box Protein O3FOXO3 protein, ratMembrane GlycoproteinsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Natriuretic Peptide, BrainNerve Tissue ProteinsNfatc4 protein, ratNFATC Transcription FactorsProto-Oncogene Proteins c-aktReactive Oxygen SpeciesRNA, Small InterferingSIRT3 protein, ratSirtuinsangiotensin IIcardiac hypertrophyCD38NFATc4SIRT3

Identifiers

PMID28296029
PMCPMC5542907
OpenAlexW2603797151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.