ArticleAngewandte Chemie (International ed. in English)2017
A Moldable Nanocomposite Hydrogel Composed of a Mussel-Inspired Polymer and a Nanosilicate as a Fit-to-Shape Tissue Sealant.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Adhesive and Hemostatic Hydrogel for the Management of Postpartum Hemorrhage.ACS applied materials & interfaces · 2026Article
- Recent advances onFundamental research · 2026Review
- Biomimetic 3D-Printed Adaptive Hydrogel Bioadhesives Featuring Superior Infection Resistance for Challenging Tissue Adhesion, Hemostasis, and Healthcare.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Chlorocatechol-functionalized gelatin nanoparticles as a hemostatic agent with antimicrobial properties.Acta biomaterialia · 2025Article
- Autoxidation-Induced Curing of 6-Hydroxycatechol-Containing Adhesive.Macromolecular chemistry and physics · 2025Article
- Design and Performance Verification of Bionic Octopus Sucker Sealing Structure for Solenoid Valves.Biomimetics (Basel, Switzerland) · 2025Article
- Robust tetra-armed poly (ethylene glycol)-based hydrogel as tissue bioadhesive for the efficient repair of meniscus tears.MedComm · 2024Article
- Photothermal driven BMSCs osteogenesis and M2 macrophage polarization on polydopamine-coated TiMaterials today. Bio · 2024Article
- Review
- Synthesis and characterisation of a novel poly(2-hydroxyethylmethacrylate)-chitosan hydrogels loaded cerium oxide nanocomposites dressing on cutaneous wound healing on nursing care of chronic wound.IET nanobiotechnology · 2023Article
- Utilizing Robust Design to Optimize Composite Bioadhesive for Promoting Dermal Wound Repair.Polymers · 2023Article
- Robust hydrogel adhesives for emergency rescue and gastric perforation repair.Bioactive materials · 2023Article
- Mussel-inspired nanoparticle composite hydrogels for hemostasis and wound healing.Frontiers in chemistry · 2023Review
- Bio-inspired adhesive hydrogel for biomedicine-principles and design strategies.Smart medicine · 2022Review
- Bio-macromolecular design roadmap towards tough bioadhesives.Chemical Society reviews · 2022Review
- Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization.Bioactive materials · 2022Article
- A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders.Gels (Basel, Switzerland) · 2022Review
- Cohesion mechanisms for bioadhesives.Bioactive materials · 2022Review
- Gelation of highly entangled hydrophobic macromolecular fluid for ultrastrong underwater in situ fast tissue adhesion.Science advances · 2022Article
- Analysis of Three-Dimensional Cell Migration in Dopamine-Modified Poly(aspartic acid)-Based Hydrogels.Gels (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The engineering of bioadhesives to bind and conform to the complex contour of tissue surfaces remains a challenge. We have developed a novel moldable nanocomposite hydrogel by combining dopamine-modified poly(ethylene glycol) and the nanosilicate Laponite, without the use of cytotoxic oxidants. The hydrogel transitioned from a reversibly cross-linked network formed by dopamine-Laponite interfacial interactions to a covalently cross-linked network through the slow autoxidation and cross-linking of catechol moieties. Initially, the hydrogel could be remolded to different shapes, could recover from large strain deformation, and could be injected through a syringe to adhere to the convex contour of a tissue surface. With time, the hydrogel solidified to adopt the new shape and sealed defects on the tissue. This fit-to-shape sealant has potential in sealing tissues with non-flat geometries, such as a sutured anastomosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.