Evidence map›Paper›PMID 28296019›Full record

ArticleHIV medicine2017

Health care provider communication training in rural Tanzania empowers HIV-infected patients on antiretroviral therapy to discuss adherence problems.

S Erb, E Letang, T R Glass, A Natamatungiro, D Mnzava, H Mapesi, M Haschke, U Duthaler, B Berger, L Muri and 7 more

Abstract readClinical Study
In one paragraph

Article in HIV medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. The WHO EQUIP Foundational Helping Skills Trainer's Curriculum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

S ErbDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland.
E LetangIfakara Health Institute, Ifakara Branch, Ifakara, Tanzania.
T R GlassSwiss Tropical and Public Health Institute of Basel, Basel, Switzerland.
A NatamatungiroIfakara Health Institute, Ifakara Branch, Ifakara, Tanzania.
D MnzavaIfakara Health Institute, Ifakara Branch, Ifakara, Tanzania.
H MapesiIfakara Health Institute, Ifakara Branch, Ifakara, Tanzania.
M HaschkeDivision of Clinical Pharmacology and Toxicology, University Hospital Basel, University of Basel, Basel, Switzerland.
U DuthalerDivision of Clinical Pharmacology and Toxicology, University Hospital Basel, University of Basel, Basel, Switzerland.
B BergerDivision of Clinical Pharmacology and Toxicology, University Hospital Basel, University of Basel, Basel, Switzerland.
L MuriSwiss Tropical and Public Health Institute of Basel, Basel, Switzerland.
J BaderMolecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
C MarzoliniDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland.
L ElziDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland.
T KlimkaitMolecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
W LangewitzInstitute of Psychosomatic Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
M BattegayDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Kilombero Ulanga Antiretroviral Cohort (KIULARCO) study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSelf-reported adherence assessment in HIV-infected patients on antiretroviral therapy (ART) is challenging and may overestimate adherence. The aim of this study was to improve the ability of health care providers to elicit patients' reports of nonadherence using a "patient-centred" approach in a rural sub-Saharan African setting.

methodsA prospective interventional cohort study of HIV-infected patients on ART for ≥ 6 months attending an HIV clinic in rural Tanzania was carried out. The intervention consisted of a 2-day workshop for health care providers on patient-centred communication and the provision of an adherence assessment checklist for use in the consultations. Patients' self-reports of nonadherence (≥ 1 missed ART dose/4 weeks), subtherapeutic plasma ART concentrations (< 2.5th percentile of published population-based pharmacokinetic models), and virological and immunological failure according to the World Health Organization definition were assessed before and after (1-3 and 6-9 months after) the intervention.

resultsBefore the intervention, only 3.3% of 299 patients included in the study reported nonadherence. Subtherapeutic plasma ART drug concentrations and virological and immunological failure were recorded in 6.5%, 7.7% and 14.5% of the patients, respectively. Two months after the intervention, health care providers detected significantly more patients reporting nonadherence compared with baseline (10.7 vs. 3.3%, respectively; P < 0.001), decreasing to 5.7% after 6-9 months. A time trend towards higher drug concentrations was observed for efavirenz but not for other drugs. The virological failure rate remained unchanged whereas the immunological failure rate decreased from 14.4 to 8.7% at the last visit (P = 0.002).

conclusionsPatient-centred communication can successfully be implemented with a simple intervention in rural Africa. It increases the likelihood of HIV-infected patients reporting problems with adherence to ART; however, sustainability remains a challenge.

Indexed as

AdultAnti-HIV AgentsChecklistFemaleHealth PersonnelHIV InfectionsHumansMaleMedication AdherenceMiddle AgedPatient-Centered CareProfessional-Patient RelationsProspective StudiesRural PopulationSelf ReportTanzaniaAnti-HIV Agentsantiretroviral therapyHIVpatient-centred communicationself-reported adherencesub-Saharan Africatherapeutic drug monitoring

Identifiers

PMID28296019
PMCPMC5599974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.