Evidence map›Paper›PMID 28296010›Full record

ReviewHemodialysis international. International Symposium on Home Hemodialysis2017

Overview of iron metabolism in health and disease.

Som Dev, Jodie L Babitt

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Hemodialysis international. International Symposium on Home Hemodialysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06104800 (Effect of Weight Loss on Hepcidin Levels and Iron Status in Subjects With Obesity.), which is not on this map. Cited by 229 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed, 4 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06104800 nacompletednot on this mapstarted 2024, after this paper: background citation

Effect of Weight Loss on Hepcidin Levels and Iron Status in Subjects With Obesity.

TypeinterventionalSponsorInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranRan2024 to 2025Enrolled42ConditionsObesity, Iron Deficiency AnemiaArmsCalorie-restricted diet with red meat, Calorie-restricted diet without red meat
3 · Its place in the literature

Who cites it

229 citing papers in PubMed, 4 syntheses or guidelines pooled it, 469 citations in OpenAlex.

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169 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Som DevDivision of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jodie L BabittDivision of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

Regulation of Iron Homeostasis by BMP SignalingR01DK087727 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BABITT, JODIE L · 2010 to 2024
$6.0M
Regulation of FGF23 in Chronic Kidney Disease (CKD) by iron and inflammationR01DK102815 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DAVID, NICOLAE VALENTIN · 2015 to 2024
$4.9M
NIDDK NIH HHS R01 DK087727NIDDK NIH HHS R01 DK102815
6 · The paper itself

Abstract

Iron is an essential element for numerous fundamental biologic processes, but excess iron is toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney disease and iron administration is a mainstay of anemia management in many patients. This review provides an overview of the essential role of iron in biology, the regulation of systemic and cellular iron homeostasis, how imbalances in iron homeostasis contribute to disease, and the implications for chronic kidney disease patients.

Indexed as

Cardiovascular DiseasesHomeostasisHumansIronIron DeficienciesIron OverloadLiver DiseasesNeoplasmsNeurodegenerative DiseasesRenal Insufficiency, ChronicIronanemiachronic kidney diseaseiron deficiencyIron metabolismiron overload

Identifiers

PMID28296010
PMCPMC5977983
OpenAlexW2597818558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.