Evidence map›Paper›PMID 28295960›Full record

ArticleAngewandte Chemie (International ed. in English)2017

Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects.

Mengxiao Yu, Chen Zhou, Li Liu, Shanrong Zhang, Shasha Sun, Julia D Hankins, Xiankai Sun, Jie Zheng

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Nanoparticles in the Treatment of Renal Fibrosis.International journal of nanomedicine · 2026
    Review
  3. Article
  4. Review
  5. Nanotherapeutics in Kidney Disease: Innovations, Challenges, and Future Directions.Journal of the American Society of Nephrology : JASN · 2025
    Review
  6. Review
  7. Article
  8. Targeted therapeutic strategies for the kidney.Expert opinion on therapeutic targets · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Ultrasmall-in-Nano: Why Size Matters.Nanomaterials (Basel, Switzerland) · 2022
    Review
  14. Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
  15. Ultrabright NIR-II Emissive Polymer Dots for Metastatic Ovarian Cancer Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  16. Targeted Drug Delivery Systems for Kidney Diseases.Frontiers in bioengineering and biotechnology · 2021
    Review
  17. Salivary Excretion of Renal-Clearable Silver Nanoparticles.Angewandte Chemie (International ed. in English) · 2020
    Article
  18. Review
  19. Article
  20. Renal clearable nanocarriers: Overcoming the physiological barriers for precise drug delivery and clearance.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mengxiao YuDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Chen ZhouDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Li LiuDepartment of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Shanrong ZhangAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shasha SunDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Julia D HankinsDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.
Xiankai SunDepartment of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.
Jie ZhengDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080, USA.

Funding

INTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4M
Surface chemistry for high-contrast fluorescence kidney imagingR01DK103363 · NIDDK · UNIVERSITY OF TEXAS DALLAS · PI ZHENG, JIE · 2014 to 2018
$1.3M
NIAID NIH HHS T32 AI005284NIDDK NIH HHS R01 DK103363
6 · The paper itself

Abstract

The success of nanomedicines in the clinic depends on our comprehensive understanding of nano-bio interactions in tumor microenvironments, which are characterized by dense leaky microvasculature and acidic extracellular pH (pH

Indexed as

Tumor MicroenvironmentAnimalsGoldHumansHydrogen-Ion ConcentrationKidneyMaleMetal NanoparticlesMiceNanomedicineNeoplasms, ExperimentalProstatic NeoplasmsTissue DistributionGoldmicrovascular densitynanoparticlesrenal clearancetumor aciditytumor targeting

Identifiers

PMID28295960
PMCPMC5560109

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.