SynthesisAddiction (Abingdon, England)2017
Internet interventions for adult illicit substance users: a meta-analysis.
Synthesis in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 11 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Prevalence of Dropout and Influencing Factors in Digital Psychosocial Intervention Trials for Adult Illicit Substance Users: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- How effective are remote and/or digital interventions as part of alcohol and drug treatment and recovery support? A systematic review and meta-analysis.Addiction (Abingdon, England) · 2025Pooled it
- The prevalence of frailty among older adults with maintenance hemodialysis: a systematic.BMC nephrology · 2025Pooled it
- Internet-based interventions for behavioral addictions: A systematic review.Journal of behavioral addictions · 2022Pooled it
- Computerized Psychological Interventions in Veterans and Service Members: Systematic Review of Randomized Controlled Trials.Journal of medical Internet research · 2022Pooled it
- Effectiveness of Live Health Professional-Led Group eHealth Interventions for Adult Mental Health: Systematic Review of Randomized Controlled Trials.Journal of medical Internet research · 2022Pooled it
- eHealth Interventions to Treat Substance Use in Pregnancy: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- The efficacy of Personalized Normative Feedback interventions across addictions: A systematic review and meta-analysis.PloS one · 2021Pooled it
- More behavioral recommendations produce more change: A meta-analysis of efficacy of multibehavior recommendations to reduce nonmedical substance use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Pooled it
- Internet interventions for adult illicit substance users: a meta-analysis.Addiction (Abingdon, England) · 2017Pooled it
- The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder.Journal of addiction medicineGuideline
- Electronic Intervention for Patient-Managed Benzodiazepine Tapering: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Web-Based Application for Reducing Methamphetamine Use Among Aboriginal and Torres Strait Islander People: Randomized Waitlist Controlled Trial.Journal of medical Internet research · 2025Trial
- Effects of a web-based relapse prevention program on abstinence: Secondary subgroup analysis of a pilot randomized controlled trial.Neuropsychopharmacology reports · 2022Trial
- A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy.Alcoholism, clinical and experimental research · 2021Trial
- Randomized pilot trial of Web-based cognitive-behavioral therapy adapted for use in office-based buprenorphine maintenance.Substance abuse · 2019Trial
- Randomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes.The American journal of psychiatry · 2018Trial
- Digital mental health tools for use by individuals in opioid use recovery: An academic scoping and commercial review.PLOS digital health · 2026Article
- Exploring motivational interviewing's technical hypothesis with emerging adults from racial or ethnic minority groups with heavy alcohol use.Journal of ethnicity in substance abuse · 2026Article
- Refining smart healthcare care for mental health and substance use disorders: A patient-centred, evidence-based approach.World journal of psychiatry · 2025Article
Corrections and comments
- Commented on by
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsResearch has shown that internet interventions can be effective for dependent users of various substances. However, less is known about the effects of these interventions on users of opioids, cocaine and amphetamines than for other substances. We aimed to investigate the effectiveness of internet interventions in decreasing the usage of these types of substances.
methodsWe conducted a systematic literature search in the databases of PubMed, PsycINFO, Embase and the Cochrane Library to identify randomized controlled trials examining the effectiveness of internet interventions compared with control conditions in reducing the use of opioids, cocaine and amphetamines. No setting restrictions were applied. The risk of bias of the included studies was examined according to the Cochrane Risk of Bias assessment tool. The primary outcome was substance use reduction assessed through toxicology screening, self-report or both at post-treatment and at the follow-up assessment.
resultsSeventeen studies with 2836 adult illicit substance users were included. The risk of bias varied across the included studies. Internet interventions decreased significantly opioid [four studies, n = 606, g = 0.36; 95% confidence interval (CI) = 0.20-0.53, P < 0.001] and any illicit substance use (nine studies, n = 1749, g = 0.35; 95% CI = 0.24-0.45, P < 0.001) at post-treatment. Conversely, the effect of internet intervention for stimulant users was small and non-significant (four studies, n = 481, P = 0.164). Overall, internet interventions decreased substance significantly use at post-treatment (17 studies, n = 2836, g = 0.31; 95% CI = 0.23-0.39, P < 0.001) and at the follow-up assessments (nine studies, n = 1906, g = 0.22; 95% CI = 0.07-0.37; P = 0.003).
conclusionsInternet interventions demonstrate small but significant effects in decreasing substance use among various target populations at post-treatment and at the follow-up assessment. However, given the small number of available studies for certain substances, the findings should be interpreted with caution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.