Evidence map›Paper›PMID 28295364›Full record

ReviewPhotochemistry and photobiology2017

Melanoma Chemoprevention: Current Status and Future Prospects.

Gagan Chhabra, Mary Ann Ndiaye, Liz Mariely Garcia-Peterson, Nihal Ahmad

Open access · bronzeAbstract readReview
In one paragraph

Review in Photochemistry and photobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Molecules (Basel, Switzerland) · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Characterization ofAntioxidants (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gagan ChhabraDepartment of Dermatology, University of Wisconsin, Madison, WI.
Mary Ann NdiayeDepartment of Dermatology, University of Wisconsin, Madison, WI.
Liz Mariely Garcia-PetersonDepartment of Dermatology, University of Wisconsin, Madison, WI.
Nihal AhmadDepartment of Dermatology, University of Wisconsin, Madison, WI.
University of Wisconsin–Madison · USWilliam S. Middleton Memorial Veterans Hospital · US

Funding

Role of Polo-Like Kinase-1 in Melanocytic TransformationR01AR059130 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI AHMAD, NIHAL · 2010 to 2019
$3.8M
Skin Diseases Research Center at the University of WisconsinP30AR066524 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI WOOD, GARY S · 2014 to 2018
$2.6M
Role of SIRT1 in melanocyte biology and melanocyte transformationR01CA176748 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AHMAD, NIHAL · 2013 to 2017
$1.6M
Plk1-Numb Cooperation in MelanomagenesisI01BX001008 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI AHMAD, NIHAL · 2013 to 2016
–
BLR&D Research Career Scientist Award ApplicationIK6BX003780 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI AHMAD, NIHAL · 2017 to 2021
–
BLRD VA I01 BX001008BLRD VA IK6 BX003780NCI NIH HHS R01 CA176748NIAMS NIH HHS P30 AR066524NIAMS NIH HHS R01 AR059130
6 · The paper itself

Abstract

The incidence of skin cancers, both nonmelanoma and melanoma, is increasing in the United States. The ultraviolet radiation, mainly from sun, is considered the major cause for these neoplasms. While nonmelanoma skin cancers are far more numerous, melanoma remains the most challenging. This is because melanoma can become extremely aggressive and its incidence is increasing worldwide due to lack of effective early detection, as well as disease recurrence, following both surgery and chemotherapy. Therefore, in addition to better treatment options, newer means are required to prevent melanomas from developing. Chemoprevention is a reasonable cost-effective approach to prevent carcinogenesis by inhibiting the processes of tumor initiation, promotion and progression. Melanoma is a progressive disease, which makes it very suitable for chemopreventive interventions, by targeting the processes and molecular pathways involved in the progression of melanoma. This review discusses the roles of various chemopreventive agents such as NSAIDs, statins, vitamins and dietary agents in melanoma and highlights current advancements and our perspective on future of melanoma chemoprevention. Although considerable preclinical data suggest that melanoma may be prevented or delayed by a numerous chemopreventive agents, we realize there are insufficient clinical studies evaluating their efficacy and long-term safety for human use.

Indexed as

Anticarcinogenic AgentsAnti-Inflammatory Agents, Non-SteroidalDietary SupplementsDisease ProgressionHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMelanomaNeoplasms, Radiation-InducedSkin NeoplasmsSunlightSunscreening AgentsUltraviolet RaysVitaminsAnticarcinogenic AgentsAnti-Inflammatory Agents, Non-SteroidalHydroxymethylglutaryl-CoA Reductase InhibitorsSunscreening AgentsVitamins

Identifiers

PMID28295364
PMCPMC5500429
OpenAlexW2606577309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.