Evidence map›Paper›PMID 28295241›Full record

ArticleImmunology2017

Indirect effects of immunological tolerance to a regular dietary protein reduce cutaneous scar formation.

Thiago Anselmo Cantaruti, Raquel Alves Costa, Kênia Soares de Souza, Nelson Monteiro Vaz, Cláudia Rocha Carvalho

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Systemic effects of oral tolerance improve the healing of several and concomitant wounds on different parts of the body.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  2. Article
  3. Temporal Modulation of Drug Desensitization Procedures.Current issues in molecular biology · 2022
    Review
  4. Subcutaneous injection of an immunologically tolerated protein up to 5 days before skin injuries improves wound healing.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022
    Article
  5. Review
  6. Article
  7. Hsp65-ProducingFrontiers in immunology · 2020
    Article
  8. Enhancement of cellular activity in hyperglycemic mice dermal wounds dressed with chitosan-alginate membranes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Thiago Anselmo CantarutiDepartamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Raquel Alves CostaUniversidade Federal de São João Del Rei, Minas Gerais, Brazil.
Kênia Soares de SouzaDepartamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Nelson Monteiro VazDepartamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Cláudia Rocha CarvalhoDepartamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0002-0385-8649
Universidade Federal de Minas Gerais · BRFederal University of São João del-Rei · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral tolerance refers to the specific inhibition of immune responsiveness to T-cell-dependent antigens contacted through the oral route before parenteral immunization. Oral tolerance to one protein does not inhibit immune responses to other unrelated proteins, but parenteral injection of tolerated antigens plus adjuvant into tolerant, but not normal, mice inhibits immune responses to antigens injected concomitantly or soon thereafter. The inhibitory effect triggered by parenteral injection of tolerated proteins is known as bystander suppression or indirect effects of oral tolerance. Intraperitoneal injection of ovalbumin (OVA) plus alum adjuvant in OVA-tolerant mice soon before skin injury inhibits inflammation and improves cutaneous wound healing. However, as OVA is not a regular component of mouse chow, we tested whether indirect effects could be triggered by zein, the main protein of corn that is regularly present in mouse chow. We show that intraperitoneal injection of a single dose (10 μg) of zein plus alum adjuvant soon before skin injury in mice reduces leucocyte infiltration but increase the number of T cells and the expression of resistin-like molecule-α (a marker of alternatively activated macrophages) in the wound bed, increases the expression of transforming growth factor-β

Indexed as

Bystander EffectImmune ToleranceImmunizationWound HealingAdjuvants, ImmunologicAlum CompoundsAnimalsCicatrixCytokinesDisease Models, AnimalInjections, IntraperitonealIntercellular Signaling Peptides and ProteinsMaleMast CellsMice, Inbred C57BLMyofibroblastsAdjuvants, ImmunologicAlum Compoundsaluminum sulfateCytokinesIntercellular Signaling Peptides and ProteinsOvalbuminRetnla protein, mouseTgfb3 protein, mouseTransforming Growth Factor beta3Zeincutaneous scarimmunological toleranceinflammationmucosaskin wound healing

Identifiers

PMID28295241
PMCPMC5461096
OpenAlexW2593673827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.