ArticleScientific reports2017
Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Diagnostic and Predictive Applications of Functional Near-Infrared Spectroscopy for Major Depressive Disorder: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Meta-analysis of physical activity and effects of social function and quality of life on the physical activity in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2019Pooled it
- Smoking Rates and Number of Cigarettes Smoked per Day in Schizophrenia: A Large Cohort Meta-Analysis in a Japanese Population.The international journal of neuropsychopharmacology · 2019Pooled it
- Effects of theta burst stimulation on cognitive function and characteristics of blood oxygen alterations based on near-infrared spectroscopy in chronic schizophrenia.BMC psychiatry · 2025Trial
- Frontal haemodynamic responses in depression and the effect of electroconvulsive therapy.Journal of psychopharmacology (Oxford, England) · 2019Trial
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders.Frontiers in neurology · 2025Article
- Causal associations of intelligence with schizophrenia and bipolar disorder: A Mendelian randomization analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Prefrontal Cortex Activation During Verbal Fluency Task and Tower of London Task in Schizophrenia and Major Depressive Disorder.Frontiers in psychiatry · 2021Article
- Polygenic risk scores for late smoking initiation associated with the risk of schizophrenia.NPJ schizophrenia · 2020Article
- Differences in executive function among patients with schizophrenia, their unaffected first-degree relatives and healthy participants.The international journal of neuropsychopharmacology · 2020Article
- Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder.Scientific reports · 2020Article
- Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives, and Healthy Participants.The international journal of neuropsychopharmacology · 2020Article
- Reduction of Onset Delay in Functional Near-Infrared Spectroscopy: Prediction of HbO/HbR Signals.Frontiers in neurorobotics · 2020Article
- A novel role of oxytocin: Oxytocin-induced well-being in humans.Biophysics and physicobiology · 2019Article
- Reduced Prefrontal Activation During the Tower of London and Verbal Fluency Task in Patients With Bipolar Depression: A Multi-Channel NIRS Study.Frontiers in psychiatry · 2018Article
- Cognitive clustering in schizophrenia patients, their first-degree relatives and healthy subjects is associated with anterior cingulate cortex volume.NeuroImage. Clinical · 2017Article
- A Brief Assessment of Intelligence Decline in Schizophrenia As Represented by the Difference between Current and Premorbid Intellectual Quotient.Frontiers in psychiatry · 2017Review
- Differences in subcortical brain volumes among patients with schizophrenia and bipolar disorder and healthy controls.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Family history (FH) is predictive of the development of major psychiatric disorders (PSY). Familial psychiatric disorders are largely a consequence of genetic factors and typically exhibit more severe impairments. Decreased prefrontal activity during verbal fluency testing (VFT) may constitute an intermediate phenotype for PSY. We investigated whether familial PSY were associated with a greater severity of prefrontal dysfunction in accordance with genetic loading. We measured prefrontal activity during VFT using near-infrared spectroscopy (NIRS) in patients with schizophrenia (SCZ, n = 45), major depressive disorder (MDD, n = 26) or bipolar disorder (BIP, n = 22) and healthy controls (HC, n = 51). We compared prefrontal activity among patients with or without FH and HC. Patients in the SCZ, MDD and BIP patient groups had lower prefrontal activity than HC subjects. Patients with and without FH in all diagnostic groups had lower prefrontal activity than HC subjects. Moreover, SCZ patients with FH had lower prefrontal activity than SCZ patients without FH. When we included patients with SCZ, MDD or BIP in the group of patients with PSY, the effects of psychiatric FH on prefrontal activity were enhanced. These findings demonstrate the association of substantially more severe prefrontal dysfunction with higher genetic loading in major psychiatric disorders.
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