Evidence map›Paper›PMID 28294982›Full record

ArticleToxins2017

Cubozoan Sting-Site Seawater Rinse, Scraping, and Ice Can Increase Venom Load: Upending Current First Aid Recommendations.

Angel Anne Yanagihara, Christie L Wilcox

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Interventions for the symptoms and signs resulting from jellyfish stings.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Article
  3. Article
  4. Cnidarian toxins: omics approaches and recombinant proteins.The journal of venomous animals and toxins including tropical diseases · 2025
    Article
  5. Jellyfish Stings: A Review of Skin Symptoms, Pathophysiology, and Management.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Review
  6. Review
  7. Article
  8. Effect of Rinse Solutions onInternational journal of environmental research and public health · 2023
    Article
  9. Raising Awareness on the Clinical and Forensic Aspects of Jellyfish Stings: A Worldwide Increasing Threat.International journal of environmental research and public health · 2022
    Review
  10. Refinement and Neutralization Evaluation of the F(ab')International journal of molecular sciences · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Angel Anne YanagiharaDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Mānoa, Honolulu, HI 96822, USA. ayanagih@hawaii.edu.
Christie L WilcoxDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Mānoa, Honolulu, HI 96822, USA. wilcoxcl@hawaii.edu.
University of Hawaiʻi at Mānoa · US

Funding

WORLDWIDE EPIDEMIOLOGY &EPIZOOTIOLOGY OF HANTAVIRUSG12RR003061 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI PANEE, JUN · 1986 to 2011
$32.3M
UHI COBRE: SOLID STATE NMR STUDIES OF MINERALIZED ELASTINP20RR016453 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI SHOHET, RALPH V. · 2001 to 2011
$21.2M
STEERING COMMITTEEU54MD008149 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI OFILI, ELIZABETH O. · 2012 to 2018
$21.1M
RESEARCH DESIGN AND BIOSTATISTICS COREU54MD007584 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI HEDGES, JERRIS ROBERT, MOKUAU, NOREEN · 2012 to 2018
$21.1M
UNIVERSITY OF HAWAII SNRPU54NS039406 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI NICHOLS, ROBERT · 1999 to 2009
$14.4M
Small Grants ProgramP30GM114737 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI YANAGIHARA, RICHARD · 2015 to 2022
$8.1M
TRPV Pharmacophores from Cnidaria VenomR21DA024444 · NIDA · UNIVERSITY OF HAWAII AT MANOA · PI YANAGIHARA, ANGEL ANNE · 2008 to 2009
$447k
Pathogenesis of Life Threatening Box Jellyfish Envenomation and Irukandji SyndromeR21ES027230 · NIEHS · UNIVERSITY OF HAWAII AT MANOA · PI YANAGIHARA, ANGEL ANNE · 2016 to 2017
$424k
NCRR NIH HHS G12 RR003061NCRR NIH HHS P20 RR016453NIDA NIH HHS R21 DA024444NIEHS NIH HHS R21 ES027230NIGMS NIH HHS P30 GM114737NIMHD NIH HHS U54 MD007584NIMHD NIH HHS U54 MD008149NINDS NIH HHS U54 NS039406
6 · The paper itself

Abstract

Cnidarian envenomations are the leading cause of severe and lethal human sting injuries from marine life. The total amount of venom discharged into sting-site tissues, sometimes referred to as "venom load", has been previously shown to correlate with tentacle contact length and sequelae severity. Since <1% of cnidae discharge upon initial tentacle contact, effective and safe removal of adherent tentacles is of paramount importance in the management of life-threatening cubozoan stings. We evaluated whether common rinse solutions or scraping increased venom load as measured in a direct functional assay of venom activity (hemolysis). Scraping significantly increased hemolysis by increasing cnidae discharge. For

Indexed as

CubozoaAnimalsBites and StingsCnidarian VenomsFirst AidIceSeawaterSkinSwineCnidarian VenomsIceAlatina alatabox jellyChironex fleckerifirst aidheat treatmenthot water immersionjellyfishmarine envenomationshaving

Identifiers

PMID28294982
PMCPMC5371860
OpenAlexW2595723276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.