Evidence map›Paper›PMID 28294355›Full record

ArticleAlcoholism, clinical and experimental research2017

Conditioned Stimulus Form Does Not Explain Failures to See Pavlovian-Instrumental-Transfer With Ethanol-Paired Conditioned Stimuli.

Richard J Lamb, Brett C Ginsburg, Charles W Schindler

Abstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard J LambDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas.ORCID http://orcid.org/0000-0001-6644-768X
Brett C GinsburgDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
Charles W SchindlerDesigner Drug Unit, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland.

Funding

Control Of Behavior By Drug InjectionsZIADA000001 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SHAHAM, YAVIN · 2009 to 2016
$8.3M
Rat ethanol self-administration: respondent instrumental interactionsR01AA012337 · NIAAA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAMB, RICHARD J · 2001 to 2016
$3.4M
NIAAA NIH HHS R01 AA012337
6 · The paper itself

Abstract

backgroundPavlovian-Instrumental-Transfer (PIT) examines the effects of associative learning upon instrumental responding. Previous studies examining PIT with ethanol (EtOH)-maintained responding showed increases in responding following presentation of an EtOH-paired conditioned stimulus (CS). Recently, we conducted 2 studies examining PIT with an EtOH-paired CS. One of these found increases in responding, while the other did not. This less robust demonstration of PIT may have resulted from the form of the CS used, as we used a 120-second light stimulus as a CS, while the previous studies used either a 120-second auditory stimulus or a 10-second light stimulus. This study examined whether using conditions similar to our earlier study, but with either a 120-second auditory or a 10-second light stimulus as a CS, resulted in more robust PIT. We also examined the reliability of our previous failure to observe PIT.

methodsThree experiments were conducted examining whether PIT was obtained using (i) a 120-second light stimulus, (ii) a 10-second light stimulus, or (iii) a 120-second auditory stimulus as CSs.

resultsWe found PIT was not obtained using (i) a 120-second light stimulus as a CS, (ii) a 10-second light stimulus as a CS, or (iii) a 120-second auditory stimulus as a CS.

conclusionsThese results suggest that CS form does not account for our earlier failure to see PIT. Rather, factors like rat strain or how EtOH drinking is induced may account for when PIT is or is not observed.

Indexed as

Acoustic StimulationAlcohol DrinkingAnimalsAssociation LearningConditioning, ClassicalEthanolExtinction, PsychologicalMaleRandom AllocationRatsRats, Inbred LewSelf AdministrationEthanolAlcoholismCravingEthanol Self-AdministrationOperant BehaviorRelapse

Identifiers

PMID28294355
PMCPMC5542406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.