ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Relationship between Duration of Untreated Psychosis and Intrinsic Corticostriatal Connectivity in Patients with Early Phase Schizophrenia.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Spontaneous Brain Activity Alterations in First-Episode Psychosis: A Meta-analysis of Functional Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2023Pooled it
- Toward precision medicine: can neuroimaging prospectively predict early treatment outcomes in schizophrenia spectrum disorders? A systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Review
- Duration of Untreated Psychosis, Treatment Response, and Resting State Functional Connectivity in Antipsychotic-Naïve First-Episode Psychosis Patients.Schizophrenia bulletin open · 2026Article
- A hybrid model for predicting response to risperidone after first-episode psychosis.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Replication of a neuroimaging biomarker for striatal dysfunction in psychosis.Molecular psychiatry · 2024Article
- Article
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- Candidate biomarkers in psychiatric disorders: state of the field.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy.Translational psychiatry · 2023Article
- Cognitive Processes and Resting-State Functional Neuroimaging Findings in High Schizotypal Individuals and Schizotypal Personality Disorder Patients: A Systematic Review.Brain sciences · 2023Review
- Short-term Medication Effects on Brain Functional Activity and Network Architecture in First-Episode psychosis: a longitudinal fMRI study.Brain imaging and behavior · 2023Article
- Cerebellar Functional Dysconnectivity in Drug-Naïve Patients With First-Episode Schizophrenia.Schizophrenia bulletin · 2023Article
- Frontostriatothalamic effective connectivity and dopaminergic function in the psychosis continuum.Brain : a journal of neurology · 2023Article
- The neurobiology of duration of untreated psychosis: a comprehensive review.Molecular psychiatry · 2023Review
- Dorsal striatial hypoconnectivity predicts antipsychotic medication treatment response in first-episode psychosis and unmedicated patients with schizophrenia.Brain and behavior · 2022Article
- Changes in corticostriatal connectivity and striatal tissue iron associated with efficacy of clozapine for treatment‑resistant schizophrenia.Psychopharmacology · 2022Article
- Cerebello-Thalamo-Cortical Hyperconnectivity Classifies Patients and Predicts Long-Term Treatment Outcome in First-Episode Schizophrenia.Schizophrenia bulletin · 2022Article
- Predicting Treatment Response in Schizophrenia With Magnetic Resonance Imaging and Polygenic Risk Score.Frontiers in genetics · 2022Article
- The effect of antipsychotics on glutamate levels in the anterior cingulate cortex and clinical response: AFrontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
Patients with first-episode psychosis experience psychotic symptoms for a mean of up to 2 years prior to initiation of treatment, and long duration of untreated psychosis (DUP) is associated with poor clinical outcomes. Meanwhile, evidence compiled from numerous studies suggests that longer DUP is not associated with structural brain abnormalities. To date, few studies have examined the relationship between DUP and functional neuroimaging measures. In the present study, we used seed-based resting-state functional connectivity to examine the impact of DUP on corticostriatal circuitry. We included 83 patients with early phase schizophrenia and minimal exposure to antipsychotic drugs (<2 years), who underwent resting state scanning while entering 12 weeks of prospective treatment with second-generation antipsychotic drugs. Functional connectivity maps of the striatum were generated and examined in relation to DUP as a covariate. Mediation analyses were performed on a composite measure of corticostriatal connectivity derived from the significant results of our DUP analysis. We found that longer DUP correlated with worse response to treatment as well as overall decreased functional connectivity between striatal nodes and specific regions within frontal and parietal cortices. Moreover, the relationship between DUP and treatment response was significantly mediated by corticostriatal connectivity. Our results indicate that variation in corticostriatal circuitry may play a role in the relationship between longer DUP and worsened response to treatment. Future prospective studies are necessary to further characterize potential causal links between DUP, striatal circuitry and clinical outcomes.
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