ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Influence of Familial Risk for Depression on Cortico-Limbic Connectivity During Implicit Emotional Processing.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 36 citations in OpenAlex.
- Functional alterations of the medial frontal gyrus as candidate biomarkers for resilience in major depressive disorder.BMC psychiatry · 2026Article
- Family history, inflammation, and cerebellum in major depression: a combined VBM and dynamic functional connectivity study.Translational psychiatry · 2025Article
- Electrocardiography-derived autonomic profiles in depression and suicide risk with insights from the UK Biobank.Npj mental health research · 2025Article
- Higher amplitudes of visual networks are associated with trait- but not state-depression.Psychological medicine · 2024Article
- Investigating two mobile just-in-time adaptive interventions to foster psychological resilience: research protocol of the DynaM-INT study.BMC psychology · 2023Article
- Dynamic Modelling of Mental Resilience in Young Adults: Protocol for a Longitudinal Observational Study (DynaM-OBS).JMIR research protocols · 2023Article
- Prefrontal cortex and depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Associating Flexible Regulation of Emotional Expression With Psychopathological Symptoms.Frontiers in behavioral neuroscience · 2022Article
- Neural correlates of RDoC-specific cognitive processes in a high-functional autistic patient: a statistically validated case report.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Multimodal brain imaging connectivity analyses of emotional and motivational deficits in depression among women.Journal of psychiatry & neuroscience : JPN · 2021Article
- Brain areas associated with resilience to depression in high-risk young women.Brain structure & function · 2021Article
- Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.Frontiers in neuroscience · 2020Article
- Neural response to emotional faces in monozygotic twins: association with familial risk of affective disordersJournal of psychiatry & neuroscience : JPN · 2019Article
- An enriched granger causal model allowing variable static anatomical constraints.NeuroImage. Clinical · 2019Article
- Experiences of Discrimination Are Associated With Greater Resting Amygdala Activity and Functional Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Using Cognitive Neuroscience to Improve Mental Health Treatment: A Comprehensive Review.Journal of the Society for Social Work and Research · 2018Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imbalances in cortico-limbic activity and functional connectivity (FC) supposedly underlie biased emotional processing and present putative intermediate phenotypes (IPs) for major depressive disorder (MDD). To prove the validity of these IPs, we assessed them in familial risk. In 70 healthy first-degree relatives of MDD patients and 70 controls, brain activity and seed-based amygdala FC were assessed during an implicit emotional processing task for fMRI containing angry and fearful faces. Using the generalized psychophysiological interaction approach, amygdala FC was assessed (a) across conditions to provide comparable data to previous studies and (b) compared between conditions to elucidate its implications for emotional processing. Associations of amygdala FC with self-reported negative affect were explored post hoc. Groups did not differ in brain activation. In relatives, amygdala FC across conditions was decreased with superior and medial frontal gyrus (SFG, MFG) and increased with subgenual and perigenual anterior cingulate cortex (sgACC, pgACC). NA was inversely correlated with amygdala FC with MFG, pgACC and their interaction in relatives. Relatives showed aberrant condition-dependent modulations of amygdala FC with visual cortex, thalamus and orbitofrontal cortex. Our results do not support imbalanced cortico-limbic activity as IP for MDD. Diminished amygdala-dorsomedial prefrontal FC in relatives might indicate insufficient regulatory capacity, which appears to be compensated by ventromedial prefrontal regions. Differential task-dependent modulations of amygdala FC are discussed as a stronger involvement of automatic instead of voluntary emotional processing pathways. Reliability and etiological implications of these results should be investigated in future studies including longitudinal designs and patient-risk-control comparisons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.