ArticleNature communications2017
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.
0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
13.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
128 citing papers in PubMed, 195 citations in OpenAlex.
- Mechanistic insights into Orai dynamics during pore opening.Channels (Austin, Tex.) · 2026Review
- Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases.Channels (Austin, Tex.) · 2026Review
- Calcium signaling in microglial immune functions: current understanding and implications for disease.Current opinion in immunology · 2026Review
- Ryanodine Receptor 1 Is Dispensable for CD4European journal of immunology · 2026Article
- Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome.Cell reports · 2026Article
- A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription.bioRxiv : the preprint server for biology · 2026Article
- STIM-Orai signaling in neurons: integrating calcium dynamics and synaptic plasticity.Cell communication and signaling : CCS · 2026Review
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- CRAC channels as targets for immunotherapy.Current opinion in immunology · 2026Review
- Genome-wide CRISPR screens in primary human natural killer cells identify countermeasures against immunosuppressive environment.Nature communications · 2026Article
- Calcium Signaling Dysregulation in Diabetic Cardiomyopathy: Roles of STIM and Orai Channels.Handbook of experimental pharmacology · 2026Review
- Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: sexually dimorphic regulatory networks linking calcium channels to the complement cascade.Frontiers in immunology · 2026Article
- Differential Sensitivity of TRPC- and ORAI-Mediated Calcium Entries to 1‑[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole Chloride (SKF-96365).ACS pharmacology & translational science · 2025Article
- Remodeling of calcium signaling and store operated calcium entry as a consequence of human neural progenitor cell differentiation.Scientific reports · 2025Article
- Article
- Orai1 is Required for Osteogenic Differentiation on Nanoparticulate Mineralized Collagen Glycosaminoglycan Materials.Macromolecular bioscience · 2025Article
- Macrophage-derived VISTA engages with LRIG1 and hinders gut epithelial repair in colitis.Cellular & molecular immunology · 2025Article
- Transient receptor potential canonical 3/5 attenuate endothelial damage-induced neointima formation without affecting endothelial cell proliferation.European journal of histochemistry : EJH · 2025Article
- Advances in Second Near-Infrared Window Photothermal Agents and Photothermal Therapy for Tumors in Interdisciplinary Medical Research.Pharmaceutics · 2025Review
- Ceramide signaling in immunity: a molecular perspective.Lipids in health and disease · 2025Review
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 3 countries.
Martin VaethExperimental Pathology Program, Department of Pathology, New York University School of Medicine, 550 First Avenue, Smilow 316, New York, New York 10016, USA.
Jun YangExperimental Pathology Program, Department of Pathology, New York University School of Medicine, 550 First Avenue, Smilow 316, New York, New York 10016, USA.
Megumi YamashitaDepartment of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Isabelle ZeeExperimental Pathology Program, Department of Pathology, New York University School of Medicine, 550 First Avenue, Smilow 316, New York, New York 10016, USA.
Miriam EcksteinNYU College of Dentistry, New York University, New York, New York 10010, USA.
Camille KnospExperimental Pathology Program, Department of Pathology, New York University School of Medicine, 550 First Avenue, Smilow 316, New York, New York 10016, USA.
Ulrike KaufmannExperimental Pathology Program, Department of Pathology, New York University School of Medicine, 550 First Avenue, Smilow 316, New York, New York 10016, USA.
Peter Karoly JaniImmunoGenes, Makkosi út 86, Budakeszi 2092, Hungary.
Rodrigo S LacruzNYU College of Dentistry, New York University, New York, New York 10010, USA.
Veit FlockerziExperimental and Clinical Pharmacology and Toxicology, School of Medicine, Saarland University, Homburg 66421, Germany.
Imre KacskovicsImmunoGenes, Makkosi út 86, Budakeszi 2092, Hungary.ORCID 0000-0002-0402-3862
Murali PrakriyaDepartment of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Stefan FeskeExperimental Pathology Program, Department of Pathology, New York University School of Medicine, 550 First Avenue, Smilow 316, New York, New York 10016, USA.
New York University · USImmunoGenes (Hungary) · HUNorthwestern University · USSaarland University · DE
Funding
Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MProduction of Targeted Null Mutations for 10,000 Genes in C57BL/6 ES CellsU01HG004085 · NHGRI · REGENERON PHARMACEUTICALS, INC. · PI VALENZUELA, DAVID MANUEL · 2006 to 2010
$25.3MInstitutional Clinical and Translational Science AwardUL1TR000038 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CRONSTEIN, BRUCE NEIL, HOCHMAN, JUDITH S · 2012 to 2014
$16.8MUCD KOMP PROJECT REPOSITORYU42RR024244 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2007 to 2010
$7.9MCRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6MStore-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4MActivation Mechanisms of Store-Operated Calcium ChannelsR01GM114210 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2015 to 2018
$1.2MIdentifying Novel Ion Channels Regulating T cell FunctionR21AI125997 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2016 to 2017
$466kModulation of ORAI2 and ORAI3 Calcium ChannelsR21AI107448 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2016 to 2017
$466kStore-operated channels in the nervous systemR56NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2012 to 2012
$344kNCATS NIH HHS UL1 TR000038NCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA016087NCRR NIH HHS U42 RR024244NHGRI NIH HHS U01 HG004085NIAID NIH HHS R01 AI097302NIAID NIH HHS R21 AI107448NIAID NIH HHS R21 AI125997NIGMS NIH HHS R01 GM114210NINDS NIH HHS R01 NS057499NINDS NIH HHS R56 NS057499
Abstract
Store-operated Ca
Indexed as
ImmunityAdoptive TransferAnimalsCalciumCell ProliferationColitisCytokinesGene DeletionGene Expression RegulationGraft vs Host DiseaseHomeostasisHumansImmunity, HumoralIon Channel GatingLymphocyte CountMacrophagesCalciumCytokinesORAI1 ProteinORAI2 Protein
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.