ArticleScientific reports2017
Aptamer-based Field-Effect Biosensor for Tenofovir Detection.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 84 citations in OpenAlex.
- Therapeutic Drug Monitoring and Point-of-Care Technologies: Opportunities and Current Challenges.Therapeutic drug monitoring · 2026Review
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- DNA Sensors for the Detection of Mercury Ions.Biosensors · 2025Review
- Precision Oncology: Advances in Drug Delivery and Imaging.Recent advances in drug delivery and formulation · 2025Review
- Organic Electrochemical Transistor Aptasensor for Interleukin-6 Detection.ACS applied materials & interfaces · 2024Article
- An ALP enzyme-based electrochemical biosensor coated with signal-amplifying BaTiONanoscale advances · 2024Article
- Aptamer-functionalized polydiacetylene biosensor for the detection of three foodborne pathogens.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine.Frontiers in pharmacology · 2024Review
- Integrated Approach from Sample-to-Answer for Grapevine Varietal Identification on a Portable Graphene Sensor Chip.ACS sensors · 2023Article
- Biomarkers and Detection Platforms for Human Health and Performance Monitoring: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors.Chemical research in Chinese universities · 2022Review
- Towards wearable and implantable continuous drug monitoring: A review.Journal of pharmaceutical analysis · 2021Review
- Influence of the Electrolyte Salt Concentration on DNA Detection with Graphene Transistors.Biosensors · 2021Article
- Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19.ACS nano · 2020Review
- Article
- Impact of Self-Assembled Monolayer Design and Electrochemical Factors on Impedance-Based Biosensing.Sensors (Basel, Switzerland) · 2020Article
- Microfluidic opportunities in printed electrolyte-gated transistor biosensors.Biomicrofluidics · 2020Article
- Aptamer-guided extracellular vesicle theranostics in oncology.Theranostics · 2020Review
- Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review.BMC chemistry · 2019Review
- Optical Biosensors for Therapeutic Drug Monitoring.Biosensors · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During medical treatment it is critical to maintain the circulatory concentration of drugs within their therapeutic range. A novel biosensor is presented in this work to address the lack of a reliable point-of-care drug monitoring system in the market. The biosensor incorporates high selectivity and sensitivity by integrating aptamers as the recognition element and field-effect transistors as the signal transducer. The drug tenofovir was used as a model small molecule. The biointerface of the sensor is a binary self-assembled monolayer of specific thiolated aptamer and 6-mercapto-1-hexanol (MCH), whose ratio was optimized by electrochemical impedance spectroscopy measurements to enhance the sensitivity towards the specific target. Surface plasmon resonance, performed under different buffer conditions, shows optimum specific and little non-specific binding in phosphate buffered saline. The dose-response behavior of the field-effect biosensor presents a linear range between 1 nM and 100 nM of tenofovir and a limit of detection of 1.2 nM. Two non-specific drugs and one non-specific aptamer, tested as stringent control candidates, caused negligible responses. The applications were successfully extended to the detection of the drug in human serum. As demonstrated by impedance measurements, the aptamer-based sensors can be used for real-time drug monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.