ReviewCurrent diabetes reports2017
How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?
Review in Current diabetes reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Interaction effect between low birthweight and resistin gene rs1862513 variant on insulin resistance and type 2 diabetes mellitus in adulthood: Toon Genome Study.Journal of diabetes investigation · 2024Article
- Effects of folic acid supplementation in pregnant mice on glucose metabolism disorders in male offspring induced by lipopolysaccharide exposure during pregnancy.Scientific reports · 2023Article
- Maternal vitamin D status in relation to infant BMI growth trajectories up to 2 years of age in two prospective pregnancy cohorts.Obesity science & practice · 2022Article
- Risk factors for left ventricular dysfunction in adulthood: role of low birth weight.ESC heart failure · 2021Article
- Association of diabetes-related variants in ADCY5 and CDKAL1 with neonatal insulin, C-peptide, and birth weight.Endocrine · 2021Article
- Comparing the Predictivity of Human Placental Gene, microRNA, and CpG Methylation Signatures in Relation to Perinatal Outcomes.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand.Scientific reports · 2021Article
- Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Maternal and Offspring Genetic Risk of Type 2 Diabetes and Offspring Birthweight Among African Ancestry Populations.The Journal of clinical endocrinology and metabolism · 2019Article
- Why and How Imprinted Genes Drive Fetal Programming.Frontiers in endocrinology · 2019Article
- Causal Association Between Birth Weight and Adult Diseases: Evidence From a Mendelian Randomization Analysis.Frontiers in genetics · 2019Article
- Genetic studies of gestational duration and preterm birth.Best practice & research. Clinical obstetrics & gynaecology · 2018Review
- Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank.International journal of epidemiology · 2018Article
- Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation.Scientific reports · 2018Article
- Birth weight and type 2 diabetes: A meta-analysis.Experimental and therapeutic medicine · 2017Article
- The challenge of diabetes in Asia.European journal of clinical nutrition · 2017Article
- Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purpose of reviewIn observational epidemiology, both low and high birth weights are associated with later type 2 diabetes. The mechanisms underlying the associations are poorly understood. We review evidence for the roles of genetic and non-genetic factors linking both sides of the birth weight distribution to risk of type 2 diabetes, focusing on contributions made by the most recent genome-wide association studies (GWAS) of birth weight. RECENT
findingsThere are now nine genetic loci robustly implicated in both fetal growth and type 2 diabetes. At many of these, the same alleles are associated both with a higher risk of type 2 diabetes and a lower birth weight. This supports the Fetal Insulin Hypothesis and reflects a general pattern for type 2 diabetes susceptibility alleles: genome-wide, there is an inverse genetic correlation with birth weight, and initial estimates suggest genetic factors explain a large part of the covariance between the two traits. However, the associations at individual loci show heterogeneity; some fetal risk alleles are associated with higher birth weight. For most of these, the association reflects their correlation with the maternal risk allele which raises maternal glucose, thus increasing fetal insulin-mediated growth. GWAS have improved our understanding of the mechanisms underlying associations between type 2 diabetes and birth weight but questions remain about the relative importance of genetic versus non-genetic factors and of maternal versus fetal genotypes. To answer these questions, future work will require well-powered analyses of parents and offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.