Evidence map›Paper›PMID 28293757›Full record

ArticleDigestive diseases and sciences2017

Glucose Variability Measures as Predictors of Oral Feeding Intolerance in Acute Pancreatitis: A Prospective Pilot Study.

Chirag J Jivanji, Varsha M Asrani, Sayali A Pendharkar, Melody G Bevan, Nicola A Gillies, Danielle H E Soo, Ruma G Singh, Maxim S Petrov

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Article in Digestive diseases and sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
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3citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

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3 · Its place in the literature

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3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chirag J JivanjiDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Varsha M AsraniDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Sayali A PendharkarDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Melody G BevanDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Nicola A GilliesDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Danielle H E SooDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Ruma G SinghDepartment of Surgery, University of Auckland, Auckland, New Zealand.
Maxim S PetrovDepartment of Surgery, University of Auckland, Auckland, New Zealand. max.petrov@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral feeding intolerance (OFI) is a common complication in patients with acute pancreatitis (AP). Variations in blood glucose are associated with impaired gastrointestinal function but, to date, measures of glucose variability have not been investigated to predict OFI in patients with AP.

aimTo investigate the usefulness of several glucose variability measures in predicting the occurrence of OFI early in the course of AP.

methodsIn this prospective cohort study, six measures of glucose variability were calculated prior to the occurrence of OFI. Multivariate binary logistic regression analyses were conducted, and the diagnostic performance and accuracy of glucose variability measures were assessed.

resultsOf the 95 prospectively enrolled patients, 21 (22%) developed OFI. After adjusting for confounders, admission blood glucose concentration and mean blood glucose concentration were significantly associated with OFI [odds ratio 1.49 (95% confidence interval 1.01-2.20) and odds ratio 1.67 (95% confidence interval 1.07-2.61), respectively]. Both admission blood glucose and mean blood glucose had an area under the curve of 0.83 and positive likelihood ratios of 6.45 and 10.19, respectively. Blood glucose concentration before refeeding, standard deviation of blood glucose concentration, coefficient of variation, and mean amplitude of glycemic excursions were not significantly associated with OFI.

conclusionIn-hospital blood glucose concentrations are associated with subsequent development of OFI in patients with AP. In particular, admission blood glucose and mean blood glucose could be useful predictors of OFI in this setting.

Indexed as

Blood GlucoseAdultAgedEatingFeeding and Eating DisordersFemaleHumansMaleMiddle AgedPancreatitisPilot ProjectsPredictive Value of TestsProspective StudiesSensitivity and SpecificityBlood GlucoseAcute pancreatitisBlood glucoseOral feeding intolerancePrediction

Identifiers

PMID28293757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.