ReviewNeuroradiology2017
Diffusion tensor imaging as a prognostic biomarker for motor recovery and rehabilitation after stroke.
Review in Neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Cerebellar Transcranial Magnetic Stimulation for Post-stroke Balance and Limb Motor Function Impairments: Meta-analyses of Random Controlled Trials and Resting-State fMRI Studies.Cerebellum (London, England) · 2024Pooled it
- Changes in synaptic density in the subacute phase after ischemic stroke: AJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Trial
- Test-retest reliability and minimal detectable change of corticospinal tract integrity in chronic stroke.Human brain mapping · 2020Trial
- Brain-Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Trial
- A Randomized Clinical Trial of a Functional Electrical Stimulation Mimic to Gait Promotes Motor Recovery and Brain Remodeling in Acute Stroke.Behavioural neurology · 2018Trial
- Machine Learning-Based Prediction of Transition to Functional Upper Limb Recovery After Intensive Inpatient Rehabilitation in Early Subacute Stroke.Journal of clinical medicine · 2026Article
- The relationship between corticospinal tract and the affected lower limb function and walking ability in subacute stroke patients: a preliminary study.Journal of physical therapy science · 2026Article
- Stroke recovery beyond initial severity: the complementary roles of brain structure and brain function in acute stroke.Brain communications · 2026Article
- Remodeling and Characterization Analysis of Corticospinal Tract in Patients with Intracerebral Hemorrhage in the Basal Ganglia.Translational stroke research · 2025Article
- Smart Clothing and Medical Imaging Innovations for Real-Time Monitoring and Early Detection of Stroke: Bridging Technology and Patient Care.Diagnostics (Basel, Switzerland) · 2025Review
- Post-stroke spontaneous motor recovery in mice can be predicted from acute-phase local field potential using machine learning.APL bioengineering · 2025Article
- How Can Robotic Devices Help Clinicians Determine the Treatment Dose for Post-Stroke Arm Paresis?Sensors (Basel, Switzerland) · 2025Article
- Microstructure of the residual corticofugal projection from primary motor cortex in chronic stroke.Brain communications · 2025Article
- Post-stroke changes in brain structure and function can both influence acute upper limb function and subsequent recovery.NeuroImage. Clinical · 2025Article
- Glymphatic system dysfunction in cerebral infarction: advances and perspectives based on DTI-derived ALPS measures.American journal of translational research · 2025Review
- Early corticospinal tract sub-pathway lesion load and integrity predict post-stroke motor outcomes.Frontiers in human neuroscience · 2025Article
- Sensitivity of diffusion tensor imaging to regional mixed cerebrovascular pathology.Brain communications · 2025Article
- Corticospinal Tract Sparing in Cervical Spinal Cord Injury.Journal of clinical medicine · 2024Article
- Usefulness of automated tractography for outcome prediction in patients with recurrent stroke.Journal of physical therapy science · 2024Article
- Neuroimaging biomarkers for predicting stroke outcomes: A systematic review.Health science reports · 2024Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDespite improved acute treatment and new tools to facilitate recovery, most patients have motor deficits after stroke, often causing disability. However, motor impairment varies considerably among patients, and recovery in the acute/subacute phase is difficult to predict using clinical measures alone, particularly in severely impaired patients. Accurate early prediction of recovery would help rationalize rehabilitation goals and improve the design of trials testing strategies to facilitate recovery.
methodsWe review the role of diffusion tensor imaging (DTI) in predicting motor recovery after stroke, in monitoring treatment response, and in evaluating white matter remodeling. We critically appraise DTI studies and discuss their limitations, and we explore directions for future study.
resultsGrowing evidence suggests that combining clinical scores with information about corticospinal tract (CST) integrity can improve predictions about motor outcome. The extent of CST damage on DTI and/or the overlap between the CST and a lesion are key prognostic factor that determines motor performance and outcome. Three main strategies to quantify stroke-related CST damage have been proposed: (i) measuring FA distal to the stroke area, (ii) measuring the number of fibers that go through the stroke with tractography, and (iii) measuring the overlap between the stroke and a CST map derived from healthy age- and gender-matched controls.
conclusionRecovery of motor function probably involves remodeling of the CST proper and/or a greater reliance on alternative motor tracts through spontaneous and treatment-induced plasticity. DTI-metrics represent promising clinical biomarkers to predict motor recovery and to monitor and predict the response to neurorehabilitative interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.