ReviewFrontiers in medicine2017
Sepsis and Immunosenescence in the Elderly Patient: A Review.
Review in Frontiers in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 2 of them syntheses that pooled it.
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Who cites it
107 citing papers in PubMed, 2 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Sarcopenia and Mortality Risk of Patients with Sepsis: A Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Guidelines for Point-of-Care Fluorescence Imaging for Detection of Wound Bacterial Burden Based on Delphi Consensus.Diagnostics (Basel, Switzerland) · 2021Guideline
- Outcomes of living donor liver transplantation in elderly Egyptian patients: a retrospective study.Langenbeck's archives of surgery · 2026Article
- Specialty-Related Differences in Adherence to Antibiotic Therapy Guidelines for Infective Endocarditis in Older Patients.Antibiotics (Basel, Switzerland) · 2026Article
- Dual-function oral nanotherapeutic mitigates sepsis-like multi-organ failure by targeting inflammatory and fibrotic pathways.Bioactive materials · 2026Article
- Single-cell transcriptomic analysis reveals immune remodeling in bone marrow during aged sepsis.GeroScience · 2026Article
- The Safety of In-Hospital Delay and the Utility of dNLR in Elderly Patients With Acute Appendicitis.World journal of surgery · 2026Article
- Article
- Factors associated with mortality in older sepsis patients: a nationwide retrospective cohort study in Germany.Age and ageing · 2026Observational
- An interpretable prediction model for severe sepsis-associated acute kidney injury in older ICU patients with sepsis: a prospective multicenter cohort study.BMC geriatrics · 2026Article
- Fulminant Aeromonas caviae bacteremia with migratory myalgia: a case report of a CTX-M-3-producing multidrug-resistant strain.BMC infectious diseases · 2026Article
- How does OA affect sepsis? An observational study and Mendelian randomization mediation analysis.Osteoarthritis and cartilage open · 2026Article
- Age- and Sex-Related Outcomes in Patients with Sepsis or Septic Shock: A Prospective Monocentric Cohort Study.Journal of clinical medicine · 2026Article
- Immunoinflammatory biomarkers for sepsis-associated acute kidney injury: a multicenter prospective cohort study.Immunity & ageing : I & A · 2026Article
- The Relationship Between the Pan-Immune-Inflammation Value (PIV) and Mortality in Elderly Critically Ill Patients with Sepsis: A Single-Centre Retrospective Study.Journal of clinical medicine · 2026Article
- Age-related differences and common pathways of lymphocyte subsets in sepsis: a comparative review of elderly and pediatric patients.Cell death & disease · 2026Review
- Comorbidities, Routine Biomarkers and Early Septic Shock Occurrence in Patients with Sepsis: A Retrospective Longitudinal Study.Diagnostics (Basel, Switzerland) · 2026Article
- Evaluation of the clinical characteristics and risk factors for in-hospital mortality amongst older persons admitted with bacteraemia in a geriatric ward - a single tertiary centre review.BMC geriatrics · 2026Article
- Development of an interpretable machine learning model for predicting in-hospital mortality in ICU patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2026Article
- The association between the Acute Physiology Score and sepsis in ICU non-surviving patients with inflammatory bowel disease: a retrospective cohort study from the eICU-CRD.Frontiers in medicine · 2026Article
47 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis is a prevalent, serious medical condition with substantial mortality and a significant consumption of health-care resources. Its incidence has increased around 9% annually in general population over the last years and specially in aged patients group. Several risk factors such as comorbidities, preadmission status, malnutrition, frailty, and an impared function in the immune system called immunosenescence are involved in the higher predisposition to sepsis in the elderly patients. Immunosenescence status consists in a functional impairment in both cell-mediated immunity and humoral immune responses and increases not only the risk for develop sepsis but also lead to more severe presentation of infection and may be is also related with a higher mortality. There is a also a concern about to admit patients in the intensive care units taking into account that the outcome of elderly patients is poorer compared to younger people. Nevertheless, the management of septic elderly patients does not differ substantially from younger people. In addition, the quality of life in septic elderly survivors is also lower than in younger people. But age, as alone factor, should not be used to determine treatment options because the poorer outcomes is thought to be due to the increased comorbidities and frailty in this group of patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.