Evidence map›Paper›PMID 28293524›Full record

ArticlePlastic and reconstructive surgery. Global open2016

Effect of Axonal Trauma on Nerve Regeneration in Side-to-side Neurorrhaphy: An Experimental Study.

Henrikki Rönkkö, Harry Göransson, Hanna-Stiina Taskinen, Pasi Paavilainen, Tero Vahlberg, Matias Röyttä

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Henrikki RönkköDepartment of Orthopaedics, Hatanpää City Hospital, Tampere, Finland; Department of Hand and Microsurgery, Tampere University Hospital, Tampere, Finland; Department of Hand Surgery, Turku University Hospital, Turku, Finland; and §Institute of Clinical Medicine, Department of Biostatistics, and Department of Pathology/Neuropathology, Turku University Hospital, University of Turku, Turku, Finland.
Harry GöranssonDepartment of Orthopaedics, Hatanpää City Hospital, Tampere, Finland; Department of Hand and Microsurgery, Tampere University Hospital, Tampere, Finland; Department of Hand Surgery, Turku University Hospital, Turku, Finland; and §Institute of Clinical Medicine, Department of Biostatistics, and Department of Pathology/Neuropathology, Turku University Hospital, University of Turku, Turku, Finland.
Hanna-Stiina TaskinenDepartment of Orthopaedics, Hatanpää City Hospital, Tampere, Finland; Department of Hand and Microsurgery, Tampere University Hospital, Tampere, Finland; Department of Hand Surgery, Turku University Hospital, Turku, Finland; and §Institute of Clinical Medicine, Department of Biostatistics, and Department of Pathology/Neuropathology, Turku University Hospital, University of Turku, Turku, Finland.
Pasi PaavilainenDepartment of Orthopaedics, Hatanpää City Hospital, Tampere, Finland; Department of Hand and Microsurgery, Tampere University Hospital, Tampere, Finland; Department of Hand Surgery, Turku University Hospital, Turku, Finland; and §Institute of Clinical Medicine, Department of Biostatistics, and Department of Pathology/Neuropathology, Turku University Hospital, University of Turku, Turku, Finland.
Tero VahlbergDepartment of Orthopaedics, Hatanpää City Hospital, Tampere, Finland; Department of Hand and Microsurgery, Tampere University Hospital, Tampere, Finland; Department of Hand Surgery, Turku University Hospital, Turku, Finland; and §Institute of Clinical Medicine, Department of Biostatistics, and Department of Pathology/Neuropathology, Turku University Hospital, University of Turku, Turku, Finland.
Matias RöyttäDepartment of Orthopaedics, Hatanpää City Hospital, Tampere, Finland; Department of Hand and Microsurgery, Tampere University Hospital, Tampere, Finland; Department of Hand Surgery, Turku University Hospital, Turku, Finland; and §Institute of Clinical Medicine, Department of Biostatistics, and Department of Pathology/Neuropathology, Turku University Hospital, University of Turku, Turku, Finland.
Turku University Hospital · FIUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSide-to-side (STS) neurorrhaphy can be performed distally to ensure timely end-organ innervation. It leaves the distal end of the injured nerve intact for further reconstruction. Despite encouraging clinical results, only few experimental studies have been published to enhance the regeneration results of the procedure. We examined the influence of different size epineural windows and degree of axonal injury of STS repair on nerve regeneration and donor nerve morbidity.

methodsThree clinically relevant repair techniques of the transected common peroneal nerve (CPN) were compared. Group A: 10-mm long epineural STS windows; group B: 2-mm long windows and partial axotomy to the donor tibial nerve; and group C: 2-mm long windows with axotomies to both nerves. Regeneration was followed by the walk track analysis, nerve morphometry, histology, and wet muscle mass calculations.

resultsThe results of the walk track analysis were significantly better in groups B and C compared with group A. The nerve fiber count, total fiber area, fiber density, and percentage of the fiber area values of CPN of the group C were significantly higher when compared with group A. The wet mass ratio of the CPN-innervated anterior tibial muscle was significantly higher in group C compared with group A. The wet mass ratio of the tibial nerve-innervated gastrocnemial muscle was higher in group A compared with the other groups.

conclusionsAll three variations of the STS repair technique showed nerve regeneration. Deliberate donor nerve axotomy enhanced nerve regeneration. A larger epineural window did not compensate the effect of axonal trauma on nerve regeneration.

Identifiers

PMID28293524
PMCPMC5222669
OpenAlexW2563709402

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.