Evidence map›Paper›PMID 28293494›Full record

ArticlePlastic and reconstructive surgery. Global open2016

Survival and Inflammatory Response in Adipose-derived Mesenchymal Stem Cell-enriched Mouse Fat Grafts.

Anadi Begic, Björn L Isfoss, Linn K Lønnerød, Alexander Vigen, Jan Ø Moskaug

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anadi BegicDepartment of Plastic Surgery, Telemark Hospital, Skien, Norway; Department of Pathology, Telemark Hospital, Skien, Norway; Department of Orthopedic Surgery, Vestfold Hospital, Tønsberg, Norway; Department of Plastic and Reconstructive Surgery, Haukeland University Hospital, Bergen, Norway; and Department of Molecular Medicine, Institute of Basic Medical Sciences and Norwegian Centre for Stem Cell Research, University of Oslo, Oslo, Norway.
Björn L IsfossDepartment of Plastic Surgery, Telemark Hospital, Skien, Norway; Department of Pathology, Telemark Hospital, Skien, Norway; Department of Orthopedic Surgery, Vestfold Hospital, Tønsberg, Norway; Department of Plastic and Reconstructive Surgery, Haukeland University Hospital, Bergen, Norway; and Department of Molecular Medicine, Institute of Basic Medical Sciences and Norwegian Centre for Stem Cell Research, University of Oslo, Oslo, Norway.
Linn K LønnerødDepartment of Plastic Surgery, Telemark Hospital, Skien, Norway; Department of Pathology, Telemark Hospital, Skien, Norway; Department of Orthopedic Surgery, Vestfold Hospital, Tønsberg, Norway; Department of Plastic and Reconstructive Surgery, Haukeland University Hospital, Bergen, Norway; and Department of Molecular Medicine, Institute of Basic Medical Sciences and Norwegian Centre for Stem Cell Research, University of Oslo, Oslo, Norway.
Alexander VigenDepartment of Plastic Surgery, Telemark Hospital, Skien, Norway; Department of Pathology, Telemark Hospital, Skien, Norway; Department of Orthopedic Surgery, Vestfold Hospital, Tønsberg, Norway; Department of Plastic and Reconstructive Surgery, Haukeland University Hospital, Bergen, Norway; and Department of Molecular Medicine, Institute of Basic Medical Sciences and Norwegian Centre for Stem Cell Research, University of Oslo, Oslo, Norway.
Jan Ø MoskaugDepartment of Plastic Surgery, Telemark Hospital, Skien, Norway; Department of Pathology, Telemark Hospital, Skien, Norway; Department of Orthopedic Surgery, Vestfold Hospital, Tønsberg, Norway; Department of Plastic and Reconstructive Surgery, Haukeland University Hospital, Bergen, Norway; and Department of Molecular Medicine, Institute of Basic Medical Sciences and Norwegian Centre for Stem Cell Research, University of Oslo, Oslo, Norway.
University of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdipose tissue-derived mesenchymal stem cells (ATMSCs) are currently used in grafting procedures in a number of clinical trials. The reconstructive role of such cells in fat graft enrichment is largely unclear. This study was undertaken to assess survival and inflammatory response in fat grafts enriched with ATMSCs in mice.

methodsATMSC-enriched adipose tissue was grafted subcutaneously in a clinically relevant manner in mice, and survival and inflammatory response were determined by bioluminescence imaging of transgenic tissue constitutively expressing luciferase or driven by inflammation in wild-type animals.

resultsOnly a minor fraction of ATMSCs transplanted subcutaneously were found to survive long term, yet fat grafts enriched with ATMSCs showed improved survival for a limited period, compared with no enrichment. NF-κB activity was transiently increased in ATMSC-enriched grafts, and the grafts responded adequately to a proinflammatory stimulus. In one animal, cells originating from the subcutaneous graft were found at a site of inflammation distant from the site of engraftment.

conclusionATMSCs display limited subcutaneous survival. Still, ATMSC enrichment may improve the outcome of adipose tissue grafting procedures by facilitating short-term graft survival and adequate inflammatory responses. Migration of cells from grafted adipose tissue requires further investigation.

Identifiers

PMID28293494
PMCPMC5222639
OpenAlexW2566012514

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.